| HUMAN-TRIAL | evidence | Comparative Effectiveness of Two Initial Combination Therapies in Patients With Recent Onset Diabetes | Mounjaro | Glycemic control · human-rct · n = 256 | — |
| HUMAN-TRIAL | evidence | Efficacy, Safety, and Treatment Satisfaction of Once-Weekly Tirzepatide in Obese Type 2 Diabetic Patients | Tirzepatide | human-rct · n = 52 | — |
| HUMAN-TRIAL | evidence | A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity | LY-3298176 | Weight & fat loss · human-rct · n = 15374 | — |
| HUMAN-TRIAL | evidence | A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes Who Have Obesity or Are Overweight | LY-3298176 | Weight & fat loss · human-rct · n = 938 | — |
| HUMAN-TRIAL | evidence | Tirzepatide for the Treatment of Concurrent Type 1 Diabetes and Overweight or Obesity | Tirzepatide | human-rct · n = 40 | — |
| HUMAN-TRIAL | evidence | Emulation of the SUMMIT Heart Failure Trial in Healthcare Claims Data | Tirzepatide | Glycemic control · human-observational · n = 11265 | — |
| HUMAN-TRIAL | evidence | A Study of Bimagrumab (LY3985863) and Tirzepatide (LY3298176), Alone or in Combination, in Participants With Obesity or Overweight With Type 2 Diabetes | LY-3298176 | Weight & fat loss · human-rct | — |
| HUMAN-TRIAL | evidence | A Study of Tirzepatide (LY3298176) Once Weekly in Adolescent Participants Who Have Obesity or Overweight With Weight-Related Comorbidities | LY-3298176 | Weight & fat loss · human-rct · n = 160 | — |
| HUMAN-TRIAL | evidence | Precision Obesity Medicine: Genetic Prediction of Response to GLP-1/GIP Agonists. | Tirzepatide | Weight & fat loss · human-observational · n = 220 | — |
| HUMAN-TRIAL | evidence | Tirzepatide's Role in Postmenopausal HR+ Breast Cancer Survivors | Tirzepatide | Weight & fat loss · n = 30 | — |
| HUMAN-TRIAL | evidence | Normal-weight Diabetes: Adipocyte-directed Therapy With Pioglitazone or Tirzepatide | Mounjaro | Glycemic control · human-rct · n = 104 | — |
| HUMAN-TRIAL | evidence | A Long-term Safety Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes | LY-3298176 | Glycemic control · human-rct · n = 443 | — |
| HUMAN-TRIAL | evidence | A Study of Tirzepatide (LY3298176) Versus Semaglutide Once Weekly as Add-on Therapy to Metformin in Participants With Type 2 Diabetes | LY-3298176 | Glycemic control · human-rct · n = 1879 | — |
| HUMAN-TRIAL | evidence | Tirzepatide in PWS, HO and GNSO | Tirzepatide | Weight & fat loss · human-observational · n = 36 | — |
| HUMAN-TRIAL | evidence | A Study of Tirzepatide (LY3298176) Versus Insulin Degludec in Participants With Type 2 Diabetes | LY-3298176 | Glycemic control · human-rct · n = 1444 | — |
| HUMAN-TRIAL | evidence | Evaluation of Tirzepatide as an Adjunct to Buprenorphine for the Treatment of Opioid Use Disorder | Mounjaro | human-rct · n = 310 | — |
| HUMAN-TRIAL | evidence | Comparative Effectiveness of Tirzepatide Versus Sitagliptin in Individuals at Cardiovascular Risk (TIRZSITA-CVOT) | Tirzepatide | human-observational · n = 49065 | — |
| HUMAN-TRIAL | evidence | Tirzepatide for Weight Loss Intervention in Early-Stage Hormone Receptor Positive/HER2 Negative Breast Cancer | Mounjaro | n = 40 | — |
| HUMAN-TRIAL | evidence | The Effects of Tirzepatide in People With Overweight/Obesity and Coronary Artery Disease | LY-3298176 | human-rct · n = 124 | — |
| HUMAN-TRIAL | evidence | Comparative Effectiveness of Tirzepatide Versus Semaglutide in Individuals With Heart Failure With Preserved Ejection Fraction | Tirzepatide | Glycemic control · human-observational · n = 28118 | — |
| HUMAN-TRIAL | evidence | Estimating the Impact of Obesity Medications on Clinical and Economic Outcomes | Zepbound | Weight & fat loss · human-observational · n = 125000 | — |
| HUMAN-TRIAL | evidence | A Research Study to See How Well CagriSema Compared to Tirzepatide Helps People With Obesity Lose Weight | Tirzepatide | Weight & fat loss · human-rct · n = 809 | — |
| HUMAN-TRIAL | evidence | A Study of Tirzepatide (LY3298176) in Healthy Participants | LY-3298176 | human-rct · n = 52 | — |
| HUMAN-TRIAL | evidence | A Study of Tirzepatide (LY3298176) Plus Mibavademab Compared With Tirzepatide Alone in Adult Participants With Obesity | LY-3298176 | Weight & fat loss · human-rct · n = 392 | — |
| HUMAN-TRIAL | evidence | A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin, SGLT2 Inhibitor or Both | Tirzepatide | Glycemic control · human-rct · n = 1023 | — |
| HUMAN-TRIAL | evidence | Safety and Efficacy of NA-931 and Tirzepatide in Adults Who Are Overweight or Obese | Tirzepatide | Weight & fat loss · human-rct · n = 224 | — |
| HUMAN-TRIAL | evidence | Effect of Tirzepatide on Brown Adipose Tissue in Obesity | Tirzepatide | Weight & fat loss · human-rct · n = 34 | — |
| HUMAN-TRIAL | evidence | Study of Tirzepatide for Recovery and Alcohol Use Management | Mounjaro | Addiction & substance use · human-rct · n = 20 | — |
| HUMAN-TRIAL | evidence | Effect of Tirzepatide on Diabetic Peripheral Sensorimotor Neuropathy | Tirzepatide | human-rct · n = 40 | — |
| HUMAN-TRIAL | evidence | Efficacy and Safety of Oral Azelaprag Plus Once Weekly Tirzepatide Compared with Tirzepatide Alone in Participants with Obesity Aged 55 Years and Over | Tirzepatide | Weight & fat loss · human-rct · n = 204 | — |
| HUMAN-TRIAL | evidence | A Study of Tirzepatide (LY3298176) in Healthy Participants and Participants With Type 2 Diabetes (T2DM) | LY-3298176 | Glycemic control · human-rct · n = 142 | — |
| HUMAN-TRIAL | evidence | CARTIZ Registry: Cartilage, Arthropathy and Imaging Under Tirzepatide in Zone-stratified Cohorts - A Four-Institute Mexican Observational Registry | Tirzepatide | Glycemic control · human-observational · n = 30 | — |
| HUMAN-TRIAL | evidence | Tirzepatide to Reduce rEcurrence And Burden After Ablation of Atrial Fibrillation | Tirzepatide | Weight & fat loss · human-rct · n = 200 | — |
| HUMAN-TRIAL | evidence | Effect of Tirzepatide and Bimagrumab on Body Composition, Insulin Sensitivity, and Bone in Adults With Obesity | Tirzepatide | Weight & fat loss · human-rct · n = 63 | — |
| HUMAN-TRIAL | evidence | Effect of Tirzepatide on Progression of Coronary Atherosclerosis Using MDCT | Mounjaro | human-rct · n = 120 | — |
| HUMAN-TRIAL | evidence | A Study of Tirzepatide (LY3298176) in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF) and Obesity: The SUMMIT Trial | LY-3298176 | Weight & fat loss · human-rct · n = 731 | — |
| HUMAN-TRIAL | evidence | A Study to Measure Stomach Emptying in Overweight Non-diabetic and Diabetic Participants Using Tirzepatide | LY-3298176 | Weight & fat loss · n = 36 | — |
| HUMAN-TRIAL | evidence | Comparative Effectiveness of Tirzepatide vs Semaglutide in Participants With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction | Tirzepatide | human-observational · n = 26000 | — |
| HUMAN-TRIAL | evidence | Pre-Surgical Tirzepatide-Assisted Weight Loss in Overweight and Obese Men With Intermediate Risk Prostate Cancer: A Pilot Feasibility Study | Tirzepatide | Glycemic control · n = 30 | — |
| HUMAN-TRIAL | evidence | A Study of Tirzepatide (LY3298176) in Chinese Participants With Type 2 Diabetes | LY-3298176 | Glycemic control · human-rct · n = 257 | — |
| HUMAN-TRIAL | evidence | Tirzepatide's Effects on Epigenetic Aging and Metabolic Restoration in Virally Suppressed People With HIV | Tirzepatide | human-observational · n = 60 | — |
| HUMAN-TRIAL | evidence | Tirzepatide for the Treatment of Cannabis Use Disorder | Tirzepatide | human-rct · n = 6 | — |
| HUMAN-TRIAL | evidence | Phase 1/2a Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Effect on Body Weight of RN3161 as Monotherapy and in Combination With Tirzepatide in Adults With Overweight and Obesity | Tirzepatide | Weight & fat loss · human-rct · n = 104 | — |
| HUMAN-TRIAL | evidence | Tirzepatide in Women With Obesity and Endometrial Intra-epithelial Neoplasia or Grade 1 Endometrial Cancer | Tirzepatide | human-rct · n = 40 | — |
| HUMAN-TRIAL | evidence | Effects of Tirzepatide on Weight Loss and Chronic Inflammation in People With HIV | Tirzepatide | n = 12 | — |
| HUMAN-TRIAL | evidence | Non-Invasive Hepatic and Metabolic Index Changes After Incretin Therapy in Overweight/Obesity | Mounjaro | Weight & fat loss · human-observational · n = 154 | — |
| HUMAN-TRIAL | evidence | Evaluate the Efficacy of TIRZEPATIDE for the Treatment of Moderate to Severe HS Hidradenitis Suppurativa | Tirzepatide | n = 20 | — |
| HUMAN-TRIAL | evidence | A Study of Tirzepatide (LY3298176) In Participants After A Lifestyle Weight Loss Program | LY-3298176 | Weight & fat loss · human-rct · n = 579 | — |
| HUMAN-TRIAL | evidence | Metabolic Interventions (Time-Restricted Eating, GLP1 Receptor Agonist, and Heart Healthy Diet) to Improve Cardiometabolic Health in Prostate Cancer Patients During Androgen Deprivation Therapy, IMPACT-ADT Trial | Tirzepatide | human-rct · n = 60 | — |
| HUMAN-TRIAL | evidence | Tolerance and Pharmacokinetic/Pharmacokinetic Study of IBI362 15mg in Patients With Moderate to Severe Obesity | Tirzepatide | Weight & fat loss · human-rct · n = 98 | — |