| HUMAN-TRIAL | evidence | Precision Obesity Medicine: Genetic Prediction of Response to GLP-1/GIP Agonists. | Tirzepatide | Weight & fat loss · human-observational · n = 220 | — |
| HUMAN-TRIAL | evidence | Comparative Effectiveness of Tirzepatide vs Semaglutide in Participants With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction | Tirzepatide | human-observational · n = 26000 | — |
| HUMAN-TRIAL | evidence | A Study of Tirzepatide (LY3298176) Plus Mibavademab Compared With Tirzepatide Alone in Adult Participants With Obesity | LY-3298176 | Weight & fat loss · human-rct · n = 392 | — |
| HUMAN-TRIAL | evidence | Multi-Site Trial of Tirzepatide for Smoking Cessation | Tirzepatide | Addiction & substance use · human-rct · n = 300 | — |
| HUMAN-TRIAL | evidence | A Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight | LY-3298176 | Weight & fat loss · human-rct · n = 905 | — |
| HUMAN-TRIAL | evidence | A Study of LY3457263 in Obese Participants | LY-3298176 | Weight & fat loss · human-rct · n = 38 | — |
| HUMAN-TRIAL | evidence | Effect of Tirzepatide on Markers of MASLD in Patients With Obesity | Mounjaro | Weight & fat loss · n = 8 | — |
| HUMAN-TRIAL | evidence | Real-World Tirzepatide Therapy in Post-Bariatric Weight Regain and Preoperative Obesity Patients | Tirzepatide | Weight & fat loss · human-observational · n = 254 | — |
| HUMAN-TRIAL | evidence | A Study of Tirzepatide (LY3298176) in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF) and Obesity: The SUMMIT Trial | LY-3298176 | Weight & fat loss · human-rct · n = 731 | — |
| HUMAN-TRIAL | evidence | A Study to Investigate Weight Management With Bimagrumab (LY3985863) and Tirzepatide (LY3298176), Alone or in Combination, in Adults With Obesity or Overweight | LY-3298176 | Weight & fat loss · human-rct · n = 252 | — |
| HUMAN-TRIAL | evidence | GIP/GLP-1RA as Adjunctive to Automated Insulin Delivery in Adults With Type 1 Diabetes | Tirzepatide | Glycemic control · human-rct · n = 42 | — |
| HUMAN-TRIAL | evidence | A Study of Weight Loss Intervention With Tirzepatide and Progestin Intrauterine Device to Treat Endometrial Hyperplasia and Grade 1 Endometrial Cancer | Tirzepatide | n = 55 | — |
| HUMAN-TRIAL | evidence | Study of Tirzepatide for Recovery and Alcohol Use Management | Mounjaro | Addiction & substance use · human-rct · n = 20 | — |
| HUMAN-TRIAL | evidence | A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes | LY-3298176 | Glycemic control · human-rct · n = 111 | — |
| HUMAN-TRIAL | evidence | A Study of the Effect of Tirzepatide on How the Body Handles Birth Control Pills in Healthy Female Participants | LY-3298176 | human-observational · n = 40 | — |
| HUMAN-TRIAL | evidence | A Study of Bimagrumab Alone (LY3985863) and Bimagrumab With Tirzepatide (LY900042) in Healthy Participants | LY-3298176 | human-rct · n = 125 | — |
| HUMAN-TRIAL | evidence | A Study of Tirzepatide (LY3298176) Compared to Dulaglutide in Participants With Type 2 Diabetes | LY-3298176 | Glycemic control · human-rct · n = 636 | — |
| HUMAN-TRIAL | evidence | A Study of LY3298176 (Tirzepatide) For the Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities | LY-3298176 | Weight & fat loss · human-rct · n = 441 | — |
| HUMAN-TRIAL | evidence | Tirzepatide and Muscle Outcomes in Obesity | Tirzepatide | Weight & fat loss · human-rct · n = 30 | — |
| HUMAN-TRIAL | evidence | Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight | LY-3298176 | Weight & fat loss · human-rct · n = 290 | — |
| HUMAN-TRIAL | evidence | Efficacy and Safety of Tirzepatide for Weight Management | Tirzepatide | Weight & fat loss · n = 440 | — |
| HUMAN-TRIAL | evidence | A Study of Tirzepatide (LY3298176) Versus Insulin Lispro (U100) in Participants With Type 2 Diabetes Inadequately Controlled on Insulin Glargine (U100) With or Without Metformin | LY-3298176 | Glycemic control · human-rct · n = 1428 | — |
| HUMAN-TRIAL | evidence | Holding vs. Continuing Incretin-based Therapies Before Upper Endoscopy | Tirzepatide | human-rct · n = 69 | — |
| HUMAN-TRIAL | evidence | A Study of Retatrutide (LY3437943) Compared to Tirzepatide (LY3298176) in Adults Who Have Obesity | LY-3298176 | Weight & fat loss · human-rct · n = 800 | — |
| HUMAN-TRIAL | evidence | A Study of Tirzepatide at Different Injection Sites in Participants With Different Body Sizes | LY-3298176 | human-rct · n = 54 | — |
| HUMAN-TRIAL | evidence | Improving Cardiovascular Disease Diagnosis and Treatment in Kazakhstan Using Metabolic Correction With GLP-1 Drugs | Mounjaro | Lipid & cardiovascular markers · human-observational · n = 120 | — |
| HUMAN-TRIAL | evidence | Tirzepatide on Atrial Fibrillation Recurrence After Catheter Ablation in Patients With Obesity and HFpEF | Mounjaro | human-rct · n = 602 | — |
| HUMAN-TRIAL | evidence | GLP-1 Receptor Agonists Post-Bariatric Surgery (GRABS) Pilot Trial | Mounjaro | Weight & fat loss · human-rct · n = 30 | — |
| HUMAN-TRIAL | evidence | A Study of Tirzepatide (LY3298176) Compared With Standard of Care in Adult Participants With Obesity and Without Diabetes (SURMOUNT-REAL UK) | LY-3298176 | Weight & fat loss · human-rct · n = 3000 | — |
| HUMAN-TRIAL | evidence | GLP-1R Actions on Muscle and the Skeleton | Tirzepatide | Weight & fat loss · human-rct · n = 50 | — |
| HUMAN-TRIAL | evidence | A Phase 2 Study Evaluating the Co-Administration of Bremelanotide With Tirzepatide for the Treatment of Obesity | Tirzepatide | Weight & fat loss · human-rct · n = 108 | — |
| HUMAN-TRIAL | evidence | The Effect of Exercise and Tirzepatide on Weight and Health Outcomes (EXER-MED) | Tirzepatide | Weight & fat loss · human-rct · n = 24 | — |
| HUMAN-TRIAL | evidence | A Study of Tirzepatide (LY3298176) Versus Semaglutide Once Weekly as Add-on Therapy to Metformin in Participants With Type 2 Diabetes | LY-3298176 | Glycemic control · human-rct · n = 1879 | — |
| HUMAN-TRIAL | evidence | A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes Mellitus | LY-3298176 | Glycemic control · human-rct · n = 318 | — |
| HUMAN-TRIAL | evidence | Subcutaneous Tirzepatide Once-weekly in Patients With Obesity and Knee Osteoarthritis (STOP KNEE-OA) | Tirzepatide | Bone & joint health · human-rct · n = 352 | — |
| HUMAN-TRIAL | evidence | Effect of Tirzepatide and Bimagrumab on Body Composition, Insulin Sensitivity, and Bone in Adults With Obesity | Tirzepatide | Weight & fat loss · human-rct · n = 63 | — |
| HUMAN-TRIAL | evidence | A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight | LY-3298176 | Weight & fat loss · human-rct · n = 2539 | — |
| HUMAN-TRIAL | evidence | Weight-loss Drug for Fertility-Sparing Treatment of Atypical Hyperplasia and Low-grade Cancer of the Endometrium | Mounjaro | n = 71 | — |
| HUMAN-TRIAL | evidence | A Study of Tirzepatide (LY3298176) In Participants After A Lifestyle Weight Loss Program | LY-3298176 | Weight & fat loss · human-rct · n = 579 | — |
| HUMAN-TRIAL | evidence | A Study of Tirzepatide (LY3298176) in Healthy Participants and Participants With Type 2 Diabetes (T2DM) | LY-3298176 | Glycemic control · human-rct · n = 142 | — |
| HUMAN-TRIAL | evidence | Tirzepatide in Women With Obesity and Endometrial Intra-epithelial Neoplasia or Grade 1 Endometrial Cancer | Tirzepatide | human-rct · n = 40 | — |
| HUMAN-TRIAL | evidence | A Study of Tirzepatide (LY3298176) in Chinese Participants With Type 2 Diabetes | LY-3298176 | Glycemic control · human-rct · n = 257 | — |
| HUMAN-TRIAL | evidence | Clinical Study of Local and Systemic Biological Impact of GLP1/GIP-Receptor Agonists in Patients With Breast Cancer: The CLARA Trial | Tirzepatide | human-rct · n = 168 | — |
| HUMAN-TRIAL | evidence | Efficacy and Safety of Tirzepatide (Spartina) in Chronic Kidney Failure | Tirzepatide | Weight & fat loss · n = 15 | — |
| HUMAN-TRIAL | evidence | Comparative Effectiveness of Two Initial Combination Therapies in Patients With Recent Onset Diabetes | Mounjaro | Glycemic control · human-rct · n = 256 | — |
| HUMAN-TRIAL | evidence | Tirzepatide-Based Prehabilitation Before Elective Ventral and Incisional Hernia Repair in Patients With Obesity | Tirzepatide | human-observational · n = 91 | — |
| HUMAN-TRIAL | evidence | Anti-obesity Pharmacotherapy and Inflammation | Mounjaro | Weight & fat loss · human-observational · n = 30 | — |
| HUMAN-TRIAL | evidence | Effects of Tirzepatide on Muscle and Vascular Health in Obese Older Adults | Zepbound | Weight & fat loss · n = 20 | — |
| HUMAN-TRIAL | evidence | Effect of Tirzepatide on Recurrence of Atrial Fibrillation After Catheter Ablation in Obese Patients | Mounjaro | Weight & fat loss · human-rct · n = 710 | — |
| HUMAN-TRIAL | evidence | Tirzepatide: Reversal of Lipotoxicity and Adipose Tissue Dysfunction in Humans With Overweight/Obesity | Mounjaro | Weight & fat loss · human-rct · n = 66 | — |