| HUMAN-TRIAL | Glucagon-Like Peptide-1 Receptor Agonists and Risk of Systemic and Ocular Vascular Complications in Patients With Type 2 Diabetes and Diabetic Retinopathy. PMID 42025665 · DOI 10.1016/j.ajo.2026.04.021 · matched on "Semaglutide" | human-observational | 173216 | none stated | 2026-08-01 |
| HUMAN-TRIAL | Comparative Study of Tirzepatide Versus Dulaglutide (SURPASS CVOT) or Semaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes NCT06779929 · matched on "Semaglutide" | human-observational | 70000 | not preregistered | — |
| HUMAN-TRIAL | Emulation of the STEP-HFpEF DM Heart Failure Trial in Healthcare Claims Data NCT06914102 · matched on "Semaglutide" | human-observational | 58387 | not preregistered | — |
| HUMAN-TRIAL | Comparative Effectiveness of Tirzepatide Versus Semaglutide in Individuals With Heart Failure With Preserved Ejection Fraction NCT06914141 · matched on "Semaglutide" | human-observational | 28118 | not preregistered | — |
| HUMAN-TRIAL | Emulating the PIONEER6 Diabetes Trial Using Healthcare Claims NCT06659679 · matched on "Semaglutide" | human-observational | 26126 | none stated | — |
| HUMAN-TRIAL | A Study of Cardiovascular Events iN Diabetes Plus NCT05441267 · matched on "Semaglutide" | human-rct | 21296 | industry-funded | — |
| HUMAN-TRIAL | A Heart Disease Study of Semaglutide in Patients With Type 2 Diabetes NCT03914326 · matched on "Semaglutide" | human-rct | 9651 | industry-funded | — |
| HUMAN-TRIAL | Trial to Evaluate Cardiovascular and Other Long-term Outcomes With Semaglutide in Subjects With Type 2 Diabetes NCT01720446 · matched on "Semaglutide" | human-rct | 3297 | industry-funded | — |
| HUMAN-TRIAL | Post-Marketing Surveillance (Special Use-results Surveillance) on Long-term Use With Ozempic® NCT04469855 · matched on "Semaglutide" | human-observational | 3217 | industry-funded | — |
| HUMAN-TRIAL | A Trial Investigating the Cardiovascular Safety of Oral Semaglutide in Subjects With Type 2 Diabetes NCT02692716 · matched on "Semaglutide" | human-rct | 3183 | industry-funded | — |
| HUMAN-TRIAL | Prediction of the SEPRA Diabetes Trial in Healthcare Claims Data NCT05577728 · matched on "Semaglutide" | human-observational | 2316 | not preregistered | — |
| HUMAN-TRIAL | A Study of Tirzepatide (LY3298176) Versus Semaglutide Once Weekly as Add-on Therapy to Metformin in Participants With Type 2 Diabetes NCT03987919 · matched on "Semaglutide" | human-rct | 1879 | industry-funded, not blinded | — |
| HUMAN-TRIAL | Efficacy and Long-term Safety of Oral Semaglutide Versus Sitagliptin in Subjects With Type 2 Diabetes NCT02607865 · matched on "Semaglutide" | human-rct | 1864 | industry-funded | — |
| HUMAN-TRIAL | A Study of Orforglipron (LY3502970) Compared With Semaglutide in Participants With Type 2 Diabetes Inadequately Controlled With Metformin NCT06045221 · matched on "Semaglutide" | human-rct | 1698 | industry-funded, not blinded | — |
| HUMAN-TRIAL | Research Study to Compare Three Doses of Semaglutide Tablets Taken Once Daily in People With Type 2 Diabetes NCT04707469 · matched on "Semaglutide" | human-rct | 1606 | industry-funded | — |
| HUMAN-TRIAL | A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes NCT03811561 · matched on "Semaglutide" | human-rct | 1500 | industry-funded | — |
| HUMAN-TRIAL | A Research Study Comparing a New Medicine Oral Semaglutide to Sitagliptin in People With Type 2 Diabetes NCT04017832 · matched on "Semaglutide" | human-rct | 1441 | industry-funded | — |
| HUMAN-TRIAL | Long Term Comparative Effectiveness of Once Weekly Semaglutide Versus Standard of Care in a Real World Adult US Population With Type 2 Diabetes - a Randomized Pragmatic Trial NCT03596450 · matched on "Semaglutide" | human-rct | 1278 | industry-funded, not blinded | — |
| HUMAN-TRIAL | Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2) NCT06260722 · matched on "Semaglutide" | human-rct | 1250 | industry-funded, not blinded | — |
| HUMAN-TRIAL | Efficacy and Safety of Semaglutide Once-weekly Versus Sitagliptin Once-daily as add-on to Metformin and/or TZD in Subjects With Type 2 Diabetes NCT01930188 · matched on "Semaglutide" | human-rct | 1231 | industry-funded | — |
| HUMAN-TRIAL | A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus NCT07662213 · matched on "Semaglutide" | human-rct | 1200 | industry-funded, not blinded | — |
| HUMAN-TRIAL | A Phase III Clinical Study to Evaluate the Efficacy and Safety of GZR18 Injection in Adult Type 2 Diabetes Mellitus NCT06778967 · matched on "Semaglutide" | human-rct | 1100 | industry-funded, not blinded | — |
| HUMAN-TRIAL | Efficacy and Safety of Semaglutide Once Weekly Versus Insulin Glargine Once Daily as add-on to Metformin With or Without Sulphonylurea in Insulin-naïve Subjects With Type 2 Diabetes NCT02128932 · matched on "Semaglutide" | human-rct | 1089 | industry-funded, not blinded | — |
| HUMAN-TRIAL | A Research Study Comparing RYBELSUS® to Other Blood Sugar Lowering Tablets in People Living in America With Type 2 Diabetes (REALYSE) NCT05035082 · matched on "Semaglutide" | human-rct | 1020 | industry-funded, not blinded | — |
| HUMAN-TRIAL | Phase III Study of UBT251 Injection in Patients With Type 2 Diabetes With Inadequate Glycemic Control on Metformin ± Sulfonylurea/SGLT2 Inhibitor Therapy (UNIGUIDE-2) NCT07653477 · matched on "Semaglutide" | human-rct | 956 | industry-funded, not blinded | — |
| HUMAN-TRIAL | A Study of HRS9531 Versus Semaglutide Once Weekly as Add-on Therapy to Metformin Monotherapy or in Combination With SGLT2 Inhibitors in Participants With Type 2 Diabetes NCT06649344 · matched on "Semaglutide" | human-rct | 884 | industry-funded, not blinded | — |
| HUMAN-TRIAL | Efficacy and Safety of Semaglutide Once-weekly Versus Sitagliptin Once-daily as add-on to Metformin in Subjects With Type 2 Diabetes (SUSTAIN - CHINA MRCT) NCT03061214 · matched on "Semaglutide" | human-rct | 868 | industry-funded | — |
| HUMAN-TRIAL | Efficacy and Safety of Oral Semaglutide Versus Empagliflozin in Subjects With Type 2 Diabetes Mellitus NCT02863328 · matched on "Semaglutide" | human-rct | 822 | industry-funded, not blinded | — |
| HUMAN-TRIAL | Efficacy and Safety of Semaglutide Once-weekly Versus Exenatide ER 2.0 mg Once-weekly as add-on to 1-2 Oral Antidiabetic Drugs (OADs) in Subjects With Type 2 Diabetes NCT01885208 · matched on "Semaglutide" | human-rct | 813 | industry-funded, not blinded | — |
| HUMAN-TRIAL | A Research Study to Compare a Medicine Called Semaglutide Against Placebo in People With Peripheral Arterial Disease and Type 2 Diabetes NCT04560998 · matched on "Semaglutide" | human-rct | 792 | industry-funded | — |
| HUMAN-TRIAL | A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in Germany, as Part of Local Clinical Practice (SURE GERMANY) NCT04261933 · matched on "Semaglutide" | human-observational | 789 | industry-funded | — |
| HUMAN-TRIAL | Efficacy and Safety of Semaglutide Versus Canagliflozin as add-on to Metformin in Subjects With Type 2 Diabetes NCT03136484 · matched on "Semaglutide" | human-rct | 788 | industry-funded | — |
| HUMAN-TRIAL | Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes Mellitus Treated With Insulin NCT03021187 · matched on "Semaglutide" | human-rct | 731 | industry-funded | — |
| HUMAN-TRIAL | Efficacy and Safety of Oral Semaglutide Versus Liraglutide and Versus Placebo in Subjects With Type 2 Diabetes Mellitus NCT02863419 · matched on "Semaglutide" | human-rct | 711 | industry-funded | — |
| HUMAN-TRIAL | Dose-finding of Semaglutide Administered Subcutaneously Once Daily Versus Placebo and Liraglutide in Subjects With Type 2 Diabetes NCT02461589 · matched on "Semaglutide" | human-rct | 706 | industry-funded | — |
| HUMAN-TRIAL | Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes Mellitus Treated With Diet and Exercise Only NCT02906930 · matched on "Semaglutide" | human-rct | 703 | industry-funded | — |
| HUMAN-TRIAL | A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Japan, as Part of Local Clinical Practice NCT04878393 · matched on "Semaglutide" | human-observational | 650 | industry-funded, not preregistered | — |
| HUMAN-TRIAL | Research Study to Look at How Well Semaglutide Works in People Living With Heart Failure, Obesity and Type 2 Diabetes NCT04916470 · matched on "Semaglutide" | human-rct | 617 | industry-funded | — |
| HUMAN-TRIAL | A Trial Comparing the Safety and Efficacy of Semaglutide Once Weekly in Monotherapy or in Combination With One OAD in Japanese Subjects With Type 2 Diabetes NCT02207374 · matched on "Semaglutide" | human-rct | 601 | industry-funded, not blinded | — |
| HUMAN-TRIAL | A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in Italy, as Part of Local Clinical Practice NCT04094415 · matched on "Semaglutide" | human-observational | 581 | industry-funded | — |
| HUMAN-TRIAL | Research Study Comparing a New Medicine Semaglutide to Liraglutide in People With Type 2 Diabetes NCT03191396 · matched on "Semaglutide" | human-rct | 577 | industry-funded, not blinded | — |
| HUMAN-TRIAL | A Research Study Looking at the Comparability of 2 Different Forms of Oral Semaglutide in Healthy People NCT05227196 · matched on "Semaglutide" | human-rct | 546 | industry-funded, not blinded | — |
| HUMAN-TRIAL | A Study of BGM0504 in Participants with Type 2 Diabetes NCT06716216 · matched on "Semaglutide" | human-rct | 537 | industry-funded, not blinded | — |
| HUMAN-TRIAL | Impact of Pharmacogenetic-Guided Treatment on Type 2 Diabetes. NCT06851962 · matched on "Semaglutide" | human-rct | 504 | none stated | — |
| HUMAN-TRIAL | Efficacy and Safety of Oral Semaglutide Using a Flexible Dose Adjustment Based on Clinical Evaluation Versus Sitagliptin in Subjects With Type 2 Diabetes Mellitus. NCT02849080 · matched on "Semaglutide" | human-rct | 504 | industry-funded, not blinded | — |
| HUMAN-TRIAL | A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Spain, as Part of Local Clinical Practice NCT05443334 · matched on "Semaglutide" | human-observational | 465 | industry-funded | — |
| HUMAN-TRIAL | A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Italy, as Part of Local Clinical Practice NCT05230615 · matched on "Semaglutide" | human-observational | 458 | industry-funded | — |
| HUMAN-TRIAL | Safety and Efficacy of Oral Semaglutide Versus Dulaglutide Both in Combination With One OAD (Oral Antidiabetic Drug) in Japanese Subjects With Type 2 Diabetes NCT03015220 · matched on "Semaglutide" | human-rct | 458 | industry-funded, not blinded | — |
| HUMAN-TRIAL | A Randomised Controlled Clinical Trial in Type 2 Diabetes Comparing Semaglutide to Placebo and Liraglutide NCT00696657 · matched on "NN9535" | human-rct | 415 | industry-funded, not preregistered | — |
| HUMAN-TRIAL | A Study to Test Whether Different Doses of BI 456906 Are Effective in Treating Adults With Type 2 Diabetes. NCT04153929 · matched on "Semaglutide" | human-rct | 413 | industry-funded | — |
| HUMAN-TRIAL | Real-world Canadian Retrospective Study Evaluating Longitudinal Semaglutide Use on Cardio-Kidney-Metabolic Outcomes NCT07424430 · matched on "Semaglutide" | human-observational | 400 | none stated | — |
| HUMAN-TRIAL | Efficacy and Safety of Semaglutide Once-weekly Versus Placebo as add-on to Basal Insulin Alone or Basal Insulin in Combination With Metformin in Subjects With Type 2 Diabetes NCT02305381 · matched on "Semaglutide" | human-rct | 397 | industry-funded | — |
| HUMAN-TRIAL | A Research Study to Understand How Oral Semaglutide Works in People With Type 2 Diabetes in India NCT05502562 · matched on "Semaglutide" | human-observational | 388 | industry-funded | — |
| HUMAN-TRIAL | Efficacy and Safety of Semaglutide Once-weekly Versus Placebo in Drug-naïve Subjects With Type 2 Diabetes NCT02054897 · matched on "Semaglutide" | human-rct | 388 | industry-funded | — |
| HUMAN-TRIAL | BALANCE-DM2 Study of Bofanglutide in Adults With Type 2 Diabetes NCT07628985 · matched on "Semaglutide" | human-rct | 374 | industry-funded, not blinded | — |
| HUMAN-TRIAL | A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in Denmark and Sweden, as Part of Local Clinical Practice (SURE DENMARK/SWEDEN) NCT03648281 · matched on "Semaglutide" | human-observational | 333 | industry-funded | — |
| HUMAN-TRIAL | Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes and Moderate Renal Impairment NCT02827708 · matched on "Semaglutide" | human-rct | 324 | industry-funded | — |
| HUMAN-TRIAL | A Study in North Macedonia Investigating Retrospective Data of Glucagon-like Peptide-1 (GLP-1) Participants With Type 2 Diabetes (T2D) in Real World Environment (RWE) Setting (MIRAGE) NCT05468632 · matched on "Semaglutide" | human-observational | 314 | industry-funded, not preregistered | — |
| HUMAN-TRIAL | Efficacy and Safety of Semaglutide Once-weekly Versus Placebo as add-on to SGLT-2i in Subjects With Type 2 Diabetes Mellitus NCT03086330 · matched on "Semaglutide" | human-rct | 302 | industry-funded | — |
| HUMAN-TRIAL | A Research Study Comparing How Well Different Doses of the Medicine UBT251 Lower Blood Sugar in People With Type 2 Diabetes NCT07668388 · matched on "Semaglutide" | human-rct | 300 | industry-funded | — |
| HUMAN-TRIAL | DOORS: A Research Study to Understand How Oral Semaglutide Works in People With Type 2 Diabetes Who Change From Dipeptidyl Peptidase-4 Inhibitor (DPP4i) Treatment to Oral Semaglutide in Italy NCT05755360 · matched on "Semaglutide" | human-observational | 291 | industry-funded, not preregistered | — |
| HUMAN-TRIAL | A Research Study Comparing Active Drug in the Blood in Healthy Participants Following Dosing of the Current and a New Formulation (C) Semaglutide Tablets NCT04109508 · matched on "Semaglutide" | human-rct | 278 | industry-funded, not blinded | — |
| HUMAN-TRIAL | A Research Study to See if Two Different Formulations of Oral Semaglutide Are Equally Safe and Effective in Reducing the Blood Sugar Level in Japanese People With Type 2 Diabetes NCT07271251 · matched on "Semaglutide" | human-rct | 264 | industry-funded, not blinded | — |
| HUMAN-TRIAL | Dose-response, Safety and Efficacy of Oral Semaglutide Versus Placebo and Versus Liraglutide, All as Monotherapy in Japanese Subjects With Type 2 Diabetes NCT03018028 · matched on "Semaglutide" | human-rct | 243 | industry-funded | — |
| HUMAN-TRIAL | A Study to Compare Different Doses of RO7795081 With a Placebo or Semaglutide in People With Type 2 Diabetes NCT07112872 · matched on "Semaglutide" | human-rct | 240 | industry-funded | — |
| HUMAN-TRIAL | Patient-Reported Adverse Events with Adjunctive Tirzepatide or Semaglutide Treatment in Adults with Type 1 Diabetes. PMID 41804758 · DOI 10.1177/15209156261423903 · matched on "Semaglutide" | human-observational | 230 | none stated | 2026-06-01 |
| HUMAN-TRIAL | A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in Spain, as Part of Local Clinical Practice NCT04067999 · matched on "Semaglutide" | human-observational | 230 | industry-funded, not preregistered | — |
| HUMAN-TRIAL | A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in The Netherlands, as Part of Local Clinical Practice (SURE NETHERLANDS) NCT03929679 · matched on "Semaglutide" | human-observational | 218 | industry-funded | — |
| HUMAN-TRIAL | A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in Switzerland, as Part of Local Clinical Practice (SURE SWITZERLAND) NCT03631186 · matched on "Semaglutide" | human-observational | 215 | industry-funded | — |
| HUMAN-TRIAL | Oral vs. Subcutaneous Semaglutide in Type 2 Diabetes Mellitus NCT07056803 · matched on "Semaglutide" | human-observational | 212 | not preregistered | — |
| HUMAN-TRIAL | A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Canada, as Part of Local Clinical Practice NCT04559815 · matched on "Semaglutide" | human-observational | 194 | industry-funded | — |
| HUMAN-TRIAL | A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Sweden, as Part of Local Clinical Practice NCT04601753 · matched on "Semaglutide" | human-observational | 194 | industry-funded | — |
| HUMAN-TRIAL | A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Saudi Arabia, as Part of Local Clinical Practice NCT05230589 · matched on "Semaglutide" | human-observational | 194 | industry-funded | — |
| HUMAN-TRIAL | A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Switzerland, as Part of Local Clinical Practice NCT04537624 · matched on "Semaglutide" | human-observational | 194 | industry-funded, not preregistered | — |
| HUMAN-TRIAL | Efficacy and safety of once-weekly cagrilintide-semaglutide (CagriSema) in adults with type 2 diabetes inadequately controlled on diet and exercise (REIMAGINE 1): a randomised, double-blind, placebo-controlled, phase 3a study. PMID 42251860 · DOI 10.1016/s2213-8587(26)00126-9 · matched on "Semaglutide" | human-rct | 189 | industry-funded | 2026-08-01 |
| HUMAN-TRIAL | A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in People With Type 2 Diabetes Treated With Diet and Exercise NCT06323174 · matched on "Semaglutide" | human-rct | 189 | industry-funded | — |
| HUMAN-TRIAL | A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Mexico, as Part of Local Clinical Practice NCT05316662 · matched on "Semaglutide" | human-observational | 187 | industry-funded | — |
| HUMAN-TRIAL | Investigation of Optimal Dosing Conditions for a Long Acting GLP-1 Analogue in Healthy Male Subjects NCT01572753 · matched on "Semaglutide" | human-rct | 161 | industry-funded, not blinded | — |
| HUMAN-TRIAL | Investigating How CagriSema, Semaglutide and Cagrilintide Regulate Insulin Effects in the Body of People With Type 2 Diabetes NCT06403761 · matched on "Semaglutide" | human-rct | 158 | industry-funded | — |
| HUMAN-TRIAL | A Clinical Trial Comparing Semaglutide in Healthy People Who Eat and Take the Medicine at Different Times NCT04513704 · matched on "Semaglutide" | human-rct | 156 | industry-funded, not blinded | — |
| HUMAN-TRIAL | A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Israel, as Part of Local Clinical Practice NCT05443568 · matched on "Semaglutide" | human-observational | 155 | industry-funded | — |
| HUMAN-TRIAL | Home-based Intervention With Semaglutide Treatment Of Neuroleptica-Related Prediabetes NCT05193578 · matched on "Semaglutide" | human-rct | 154 | none stated | — |
| HUMAN-TRIAL | A Research Study to See How a New Weekly Insulin, Insulin Icodec When Given Along With Semaglutide Helps in Reducing the Blood Sugar Level in Patients With Type 2 Diabetes NCT05813912 · matched on "Semaglutide" | not determined | 148 | industry-funded, not blinded | — |
| HUMAN-TRIAL | A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in The Netherlands, as Part of Local Clinical Practice NCT04601740 · matched on "Semaglutide" | human-observational | 145 | industry-funded | — |
| HUMAN-TRIAL | Semaglutide Treatment in the Real-world for Fibrosis Due to NAFLD in Obesity and T2DM NCT06005012 · matched on "Semaglutide" | human-rct | 120 | not preregistered | — |
| HUMAN-TRIAL | Semaglutide GLP1 Agonists With Degludec Basal-bolus Insulin in Early Type 1 Diabetes to Basal-bolus NCT06057077 · matched on "Semaglutide" | human-rct | 120 | none stated | — |
| HUMAN-TRIAL | Analyse the Effect of Semaglutide on Vascular Structure and Function in Patients With Early Type 2 Diabetes NCT05303857 · matched on "Semaglutide" | human-rct | 107 | not preregistered | — |
| HUMAN-TRIAL | A Research Study to Find Out How Semaglutide Works in the Kidneys Compared to Placebo, in People With Type 2 Diabetes and Chronic Kidney Disease (the REMODEL Trial) NCT04865770 · matched on "Semaglutide" | human-rct | 106 | industry-funded | — |
| HUMAN-TRIAL | Efficacy and Safety of Empagliflozin or Semaglutide in Overweight/Obese Patients With Type 1 Diabetes NCT06762314 · matched on "Semaglutide" | human-rct | 105 | not blinded | — |
| HUMAN-TRIAL | Research Study Comparing Different Tablets With the Study Medicine Semaglutide in Healthy Men NCT03638778 · matched on "Semaglutide" | human-rct | 105 | industry-funded, not blinded | — |
| HUMAN-TRIAL | Safety Study of Weekly Semaglutide in Chilean Participants With Type 2 Diabetes NCT05533632 · matched on "Semaglutide" | not determined | 104 | industry-funded, not preregistered, not blinded | — |
| HUMAN-TRIAL | Semaglutide for Smoking Cessation in Patients With Diabetes NCT07059377 · matched on "Semaglutide" | human-rct | 100 | not blinded | — |
| HUMAN-TRIAL | The Impact of Semaglutide Compared to Energy Restriction on Type 2 Diabetes NCT07272343 · matched on "Semaglutide" | human-rct | 100 | not preregistered, not blinded | — |
| HUMAN-TRIAL | Therapeutic Effects and Effects on Body Fat of GLP-1 Receptor Agonists in Patients With Type 2 Diabetes for 1-4 Years NCT05990374 · matched on "Semaglutide" | human-rct | 100 | none stated | — |
| HUMAN-TRIAL | Glucagon-like-peptide-1 Receptor Agonists in Patients Receiving Maintenance Dialysis NCT07017270 · matched on "Semaglutide" | human-rct | 100 | not blinded | — |
| HUMAN-TRIAL | A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Denmark, as Part of Local Clinical Practice NCT04537637 · matched on "Semaglutide" | human-observational | 99 | industry-funded | — |
| HUMAN-TRIAL | Menopausal Hormone Therapy, GLP-1 Agonists, and Glucose and Energy Homeostasis in Postmenopausal Women With Diabetes NCT06715514 · matched on "Semaglutide" | human-rct | 96 | not blinded | — |
| HUMAN-TRIAL | Investigation on Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of NN9924 in Healthy Male Subjects NCT01272973 · matched on "Semaglutide" | human-rct | 96 | industry-funded | — |
| HUMAN-TRIAL | A Study to See the Effect of NNC0194-0499 Alone or in Combination With Semaglutide on Blood Sugar Control in People Living With Type 1 Diabetes NCT07087795 · matched on "Semaglutide" | human-rct | 96 | industry-funded | — |
| HUMAN-TRIAL | Research Study to Look at How Well Cagrilintide Together With Semaglutide Works in People With Type 2 Diabetes NCT04982575 · matched on "Semaglutide" | human-rct | 92 | industry-funded | — |
| HUMAN-TRIAL | A Research Study Looking at New Protein-based Tablets in Healthy Men - Oral Formulation IV NCT06642584 · matched on "Semaglutide" | human-rct | 90 | industry-funded, not blinded | — |
| HUMAN-TRIAL | A Clinical Trial to Examine the Efficacy and Safety of an Investigational Product With and Without Use of Semaglutide on Glycemic Response in Adults With Prediabetes or Type 2 Diabetes NCT07195994 · matched on "Semaglutide" | human-rct | 90 | industry-funded | — |
| HUMAN-TRIAL | A Trial Investigating the Effects of Semaglutide on ß-cell Function in Subjects With Type 2 Diabetes NCT02212067 · matched on "Semaglutide" | human-rct | 87 | industry-funded | — |
| HUMAN-TRIAL | Safety, Tolerability, and Profile of Action of Drug in the Body of NN9535 in Healthy Male Japanese and Caucasian Subjects NCT00851773 · matched on "NN9535" | human-rct | 84 | industry-funded | — |
| HUMAN-TRIAL | GLP1-RAs Effects on Inflammatory and Endothelial Biomarkers in T2DM NCT07314684 · matched on "Semaglutide" | human-rct | 80 | not preregistered, not blinded | — |
| HUMAN-TRIAL | A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in Children and Adolescents With Type 2 Diabetes NCT07282613 · matched on "Semaglutide" | human-rct | 80 | industry-funded | — |
| HUMAN-TRIAL | Effect of Food on the Pharmacokinetics of Oral Semaglutide in Healthy Subjects NCT02172313 · matched on "Semaglutide" | human-rct | 78 | industry-funded, not blinded | — |
| HUMAN-TRIAL | Efficacy and Safety of Mazdutide in Patients With Type 2 Diabetes Mellitus and Moderate to Severe Nonalcoholic Fatty Liver Disease Previously Treated With Semaglutide NCT07713992 · matched on "Semaglutide" | human-rct | 72 | not blinded | — |
| HUMAN-TRIAL | Pharmacokinetics, Safety and Tolerability of Oral Semaglutide in Subjects With Various Degrees of Impaired Renal Function NCT02014259 · matched on "Semaglutide" | human-observational | 71 | industry-funded, not preregistered, not blinded | — |
| HUMAN-TRIAL | A Research Study Looking at Similarity Between Once-weekly Semaglutide Versions for Different Injection Pens NCT04152915 · matched on "Semaglutide" | human-rct | 68 | industry-funded, not blinded | — |
| HUMAN-TRIAL | Rapid and Simultaneous Initiation of Four Guideline-Directed CKD Therapies (RAPID-CKD) NCT07547878 · matched on "Semaglutide" | human-rct | 64 | not blinded | — |
| HUMAN-TRIAL | Effect of Renal Impairment on the Pharmacokinetics of NN9535 NCT00833716 · matched on "NN9535" | human-observational | 62 | industry-funded, not blinded | — |
| HUMAN-TRIAL | The GAPSID Study - How GLP-1 Analogues Prevent Steroid-Induced Diabetes NCT06318442 · matched on "Semaglutide" | human-rct | 60 | none stated | — |
| HUMAN-TRIAL | Trial of Semaglutide for Diabetic Kidney Disease in Type 1 Diabetes NCT05822609 · matched on "Semaglutide" | human-rct | 60 | none stated | — |
| HUMAN-TRIAL | The Role of Glucagon-Like Peptide-1 Receptor Agonists in Coronary Artery Diseases and Their Potential Mechanisms NCT07073053 · matched on "Semaglutide" | human-rct | 60 | not blinded | — |
| HUMAN-TRIAL | Semaglutide vs Sitagliptin NCT05195944 · matched on "Semaglutide" | human-rct | 58 | industry-funded | — |
| HUMAN-TRIAL | Dose Escalation Trial of Single Subcutaneous Doses of NNC 0113-0217 to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Healthy Male Subjects NCT03144271 · matched on "NNC 0113-0217" | human-rct | 58 | industry-funded, not preregistered | — |
| HUMAN-TRIAL | Investigation of the Effect of Upper Gastrointestinal Disease on the Pharmacokinetics of Oral Semaglutide in Subjects With Type 2 Diabetes. NCT02877355 · matched on "Semaglutide" | not determined | 55 | industry-funded, not blinded | — |
| HUMAN-TRIAL | A Trial to Compare Blood Concentration Levels of Semaglutide Following Subcutaneous Injections of Semaglutide 1 mg by 2 Different Devices (the DV3372 Device and by the PDS290 Semaglutide Pen-injector) NCT03611322 · matched on "Semaglutide" | human-rct | 54 | industry-funded | — |
| HUMAN-TRIAL | A Trial Investigating the Influence of Oral Semaglutide on the Pharmacokinetics of Lisinopril and Warfarin in Healthy Subjects NCT02070510 · matched on "Semaglutide" | human-observational | 52 | industry-funded, not blinded | — |
| HUMAN-TRIAL | Semaglutide and Intestinal Iron Absorption NCT06629688 · matched on "Semaglutide" | not determined | 51 | not preregistered, not blinded | — |
| HUMAN-TRIAL | The Effect of Semaglutide on Cardiovascular Markers and Liver Function NCT06301191 · matched on "Semaglutide" | human-observational | 50 | not preregistered | — |
| HUMAN-TRIAL | The Ameliorative Effects of GLP-1RA on Diabetic Cardiac Autonomatic Neuropathy NCT06461377 · matched on "Semaglutide" | human-rct | 50 | none stated | — |
| HUMAN-TRIAL | A Trial to Assess the Pharmacokinetics, Pharmacodynamics, and the Safety and Tolerability of Semaglutide in Healthy Male Japanese and Caucasian Subjects NCT02146079 · matched on "Semaglutide" | human-rct | 44 | industry-funded | — |
| HUMAN-TRIAL | A Clinical Trial Investigating the Comparison of Three Different Concentrations of NN9535 in Healthy Male Subjects NCT00813020 · matched on "NN9535" | human-rct | 44 | industry-funded | — |
| HUMAN-TRIAL | Investigating the Pharmacokinetics, Safety and Tolerability After a Single Subcutaneous Injection of Semaglutide in Subjects With Mild, Moderate or Severe Hepatic Impairment Compared to Subjects With Normal Hepatic Function NCT02210871 · matched on "Semaglutide" | human-rct | 44 | industry-funded, not blinded | — |
| HUMAN-TRIAL | Impact of oral semaglutide on quality of life and metabolic parameters in patients with type 2 diabetes mellitus: A multicenter observational study. PMID 41651756 · DOI 10.1016/j.endien.2026.501713 · matched on "semaglutida" | human-observational | 43 | none stated | 2026-03-01 |
| HUMAN-TRIAL | Effect of Oral Contraceptives After Administration of Semaglutide in Subjects With Type 2 Diabetes NCT01324505 · matched on "Semaglutide" | human-observational | 43 | industry-funded, not blinded | — |
| HUMAN-TRIAL | A Trial Investigating the Effect of Oral Semaglutide on the Pharmacokinetics of Furosemide and Rosuvastatin in Healthy Subjects NCT03010475 · matched on "Semaglutide" | not determined | 41 | industry-funded, not blinded | — |
| HUMAN-TRIAL | A Trial Investigating the Effect of Semaglutide on Hypoglycaemic Counterregulation Compared to Placebo in Subjects With Type 2 Diabetes NCT02147431 · matched on "Semaglutide" | human-rct | 38 | industry-funded | — |
| HUMAN-TRIAL | A Clinical Trial to Evaluate The Effects of Semaglutide and Empagliflozin Combined to Automated Insulin Delivery on Diabetes Control in Adults Living With Type 1 Diabetes NCT06894784 · matched on "Semaglutide" | human-rct | 36 | none stated | — |
| HUMAN-TRIAL | A Trial to Assess the Pharmacokinetics, Safety and Tolerability of Semaglutide in Healthy Chinese Subjects NCT03288740 · matched on "Semaglutide" | human-rct | 36 | industry-funded | — |
| HUMAN-TRIAL | A Trial to Evaluate Safety, Feasibility and Efficacy of the ReCET Procedure (EMINENT-2) NCT05984238 · matched on "Semaglutide" | human-rct | 33 | none stated | — |
| HUMAN-TRIAL | A Research Study of How Oral Semaglutide Tablets Work in Healthy People Who Are Chinese NCT04016974 · matched on "Semaglutide" | human-rct | 32 | industry-funded | — |
| HUMAN-TRIAL | Exercise and GLP-1 RA on Insulin Secretion NCT04383197 · matched on "Semaglutide" | human-rct | 30 | not preregistered, not blinded | — |
| HUMAN-TRIAL | A Randomised, Single Centre, Double-blind, Two-period, Cross-over Trial in Healthy Subjects Investigating the Bioequivalence Between Subcutaneous Injections of Semaglutide Produced by Two Manufacturing Processes NCT01766245 · matched on "Semaglutide" | human-rct | 28 | industry-funded | — |
| HUMAN-TRIAL | Pharmacoscintigraphic Investigation of NN9924 in Healthy Male Subjects NCT01619345 · matched on "Semaglutide" | human-rct | 27 | industry-funded, not blinded | — |
| HUMAN-TRIAL | A Research Study Looking Into the Effect of Semaglutide and NNC0480 0389 on Blood Levels of a Birth Control Pill in Woman After Menopause NCT05153564 · matched on "Semaglutide" | not determined | 27 | industry-funded, not blinded | — |
| HUMAN-TRIAL | Alleviating Carbohydrate Counting for Patients with Type-1 Diabetes Using a Closed Loop System with Weekly Subcutaneous Semaglutide NCT06387199 · matched on "Semaglutide" | human-rct | 26 | none stated | — |
| HUMAN-TRIAL | A Trial Investigating the Influence of Oral Semaglutide on Pharmacokinetics of Ethinylestradiol and Levonorgestrel in an Oral Contraceptive Combination Drug in Healthy Postmenopausal Females NCT02845219 · matched on "Semaglutide" | not determined | 25 | industry-funded, not blinded | — |
| HUMAN-TRIAL | Influence of Semaglutide on Pharmacokinetics and Pharmacodynamics of Warfarin and Pharmacokinetics of Metformin in Healthy Subjects NCT02022254 · matched on "Semaglutide" | not determined | 24 | industry-funded, not blinded | — |
| HUMAN-TRIAL | A Research Study of How the Medicine NNC0480-0389 Taken With Semaglutide Works in the Body of Healthy Japanese Men NCT04878406 · matched on "Semaglutide" | human-rct | 24 | industry-funded | — |
| HUMAN-TRIAL | Does the Hematopoietic Stem Cell Govern Residual Inflammatory Cardiovascular Risk in Type 2 Diabetes NCT05597202 · matched on "Semaglutide" | not determined | 22 | not blinded | — |
| HUMAN-TRIAL | A Trial Investigating the Effect of Probenecid and Ciclosporin on the Concentrations of SNAC in Healthy Subjects NCT03466567 · matched on "Semaglutide" | human-rct | 21 | industry-funded, not blinded | — |
| HUMAN-TRIAL | Investigating the Impact of GLP-1 RA Therapy on Osteosarcopenia in Older Female Adults With Diabetes NCT07428746 · matched on "Semaglutide" | not determined | 20 | not blinded | — |
| HUMAN-TRIAL | A Research Trial Looking at the Comparability of 2 Different Concentrations of Semaglutide for the 0.5 Milligram (mg) Dose NCT05689099 · matched on "Semaglutide" | human-rct | 20 | industry-funded, not blinded | — |
| HUMAN-TRIAL | A Clinical Trial Looking at the Comparability of 2 Different Forms of Semaglutide NCT05232708 · matched on "Semaglutide" | human-rct | 18 | industry-funded, not blinded | — |
| HUMAN-TRIAL | A Research Study Looking Into Blood Levels of Semaglutide and NNC0480-0389 When Given in the Same Injection or in Two Separate Injections in Healthy People NCT05046873 · matched on "Semaglutide" | human-rct | 16 | industry-funded, not preregistered | — |
| HUMAN-TRIAL | A Trial Investigating the Effect of Oral Semaglutide Compared With Placebo on Postprandial Glucose and Triglyceride Metabolism, Energy Intake, Appetite Sensations and Gastric Emptying in Subjects With Type 2 Diabetes NCT02773381 · matched on "Semaglutide" | human-rct | 15 | industry-funded | — |
| HUMAN-TRIAL | GLP-1 RA for Stage 1 Type 1 Diabetes NCT07430332 · matched on "Semaglutide" | human-rct | 15 | none stated | — |
| HUMAN-TRIAL | A Study to Evaluate Safety, Tolerability and pK of Semaglutide ER Injectable Suspension in Healthy, Adult Human Subjects NCT06422624 · matched on "Semaglutide" | human-observational | 14 | industry-funded, not blinded | — |
| HUMAN-TRIAL | A Research Study to See How Much Semaglutide and SNAC is in the Milk of Healthy, Breastfeeding Women Taking Semaglutide Tablets NCT04817644 · matched on "Semaglutide" | not determined | 14 | industry-funded, not blinded | — |
| HUMAN-TRIAL | Comparison of Oral Semaglutide w/ Placebo- Treatment for Latino Adults w/T2 Diabetes Receiving Enhanced Lifestyle Care NCT04938388 · matched on "Semaglutide" | human-rct | 12 | industry-funded | — |
| HUMAN-TRIAL | Impact of Semaglutide on CD34+ EPC and Fat Derived MSC NCT04126603 · matched on "Semaglutide" | human-rct | 10 | not preregistered | — |
| HUMAN-TRIAL | Semaglutide in CFRD NCT05788965 · matched on "Semaglutide" | not determined | 8 | not blinded | — |
| HUMAN-TRIAL | Trial Investigating the Absorption, Metabolism and Excretion After a Single Subcutaneous Dose of [3H]-Semaglutide in Healthy Male Subjects NCT02060266 · matched on "Semaglutide" | human-observational | 7 | industry-funded, not blinded | — |
| HUMAN-TRIAL | Treatment of GLP-1 for Diabetic Bariatric Patients NCT04624672 · matched on "Semaglutide" | human-rct | 3 | industry-funded | — |
| HUMAN-TRIAL | Research Study to Compare Semaglutide Tablets With Empagliflozin or Metformin Tablets in People With Type 2 Diabetes NCT06083675 · matched on "Semaglutide" | human-rct | 0 | industry-funded, not blinded | — |
| HUMAN-TRIAL | SUSTAIN SWITCH: A Research Study to Compare Two Dose Schedules of Semaglutide Taken Once Weekly in People With Type 2 Diabetes NCT04287179 · matched on "Semaglutide" | human-rct | 0 | industry-funded, not blinded | — |
| HUMAN-TRIAL | Multi-Parametric Magnetic Resonance Imaging to Assess Empagliflozin Effect on the Kidneys in People With Type 2 Diabetes Mellitus: A Pilot Clinical Trial. PMID 42244145 · DOI 10.1111/dom.70950 · matched on "Semaglutide" | human-rct | — | none stated | 2026-08-01 |
| HUMAN-TRIAL | Evaluation of the Safety, Efficacy and Pharmacokinetics of BGM0504 in Chinese Adults With Type 2 Diabetes: A Multicentre, Randomised, Controlled and Double-Blind Phase II Trial. PMID 42219225 · DOI 10.1111/dom.70849 · matched on "Semaglutide" | human-rct | — | none stated | 2026-08-01 |
| HUMAN-TRIAL | The impact of automated insulin delivery on glucose management in people with diabetes and advanced chronic kidney disease. PMID 42108331 · DOI 10.1007/s00125-026-06732-3 · matched on "Semaglutide" | human-rct | — | none stated | 2026-08-01 |
| HUMAN-TRIAL | Cagrilintide-semaglutide (CagriSema) versus semaglutide or cagrilintide in people with type 2 diabetes (REIMAGINE 2): a double-blind, randomised, controlled, phase 3 study. PMID 42251859 · DOI 10.1016/s2213-8587(26)00125-7 · matched on "Semaglutide" | human-rct | — | none stated | 2026-08-01 |
| HUMAN-TRIAL | Association of GLP-1 receptor agonists with alcohol use disorder-related and substance use disorder-related hospital admissions during treatment and after discontinuation: a Swedish register-based within-individual observational study. PMID 42456704 · DOI 10.1016/s2215-0366(26)00172-0 · matched on "Semaglutide" | human-observational | — | none stated | 2026-08-01 |
| HUMAN-TRIAL | Cagrilintide-semaglutide (CagriSema) as an add-on to basal insulin in adults with type 2 diabetes (REIMAGINE 3): a randomised, double-blind, placebo-controlled, multicentre, phase 3 study. PMID 42251856 · DOI 10.1016/s0140-6736(26)01022-6 · matched on "Semaglutide" | human-rct | — | none stated | 2026-07-04 |
| HUMAN-TRIAL | Short-term comparative effects of semaglutide, either alone or in conjunction with canagliflozin, on early diabetic kidney disease. PMID 42170981 · DOI 10.36721/pjps.2026.39.7.204.1 · matched on "Semaglutide" | human-rct | — | none stated | 2026-07-01 |
| HUMAN-TRIAL | Cardiometabolic and Renal Outcomes in Semaglutide Users with Type 2 Diabetes Achieving Glycemic and Weight Goals: An Observational Cohort Study. PMID 42060161 · DOI 10.1007/s12325-026-03610-7 · matched on "Semaglutide" | human-observational | — | none stated | 2026-07-01 |
| HUMAN-TRIAL | Semaglutide Treatment in Young Adults Living With Type 2 Diabetes: A Post Hoc Analysis From the SUSTAIN and PIONEER Clinical Trials. PMID 41994903 · DOI 10.1111/dom.70770 · matched on "Semaglutide" | human-rct | — | none stated | 2026-07-01 |
| HUMAN-TRIAL | Differential Impact of Metabolic Bariatric Surgery Versus Semaglutide on Adverse Hepatic and Extrahepatic Outcomes in Individuals With Metabolic Dysfunction-Associated Steatotic Liver Disease and Type 2 Diabetes. PMID 41969188 · DOI 10.1111/dom.70757 · matched on "Semaglutide" | human-observational | — | none stated | 2026-07-01 |
| HUMAN-TRIAL | Effects of a 6-week subcutaneous infusion of native GIP alone or as add-on to semaglutide in people with type 2 diabetes: a single-centre, double-blind, parallel-group, randomised, placebo-controlled trial. PMID 42173109 · DOI 10.1016/s2213-8587(26)00075-6 · matched on "Semaglutide" | human-rct | — | none stated | 2026-07-01 |
| HUMAN-TRIAL | Renal or Hepatic Impairment Does Not Affect Pharmacokinetics, Safety, or Tolerability of Subcutaneous Cagrilintide. PMID 42228334 · DOI 10.1007/s40262-026-01654-0 · matched on "Semaglutide" | human-rct | — | none stated | 2026-07-01 |
| HUMAN-TRIAL | Elecoglipron, an oral small molecule GLP-1 receptor agonist in adults with type 2 diabetes (SOLSTICE): a multicentre, phase 2b, randomised, placebo-controlled trial. PMID 42259343 · DOI 10.1016/s0140-6736(26)00802-0 · matched on "Semaglutide" | human-rct | — | none stated | 2026-06-20 |
| HUMAN-TRIAL | Kidney and Survival Benefits of Semaglutide in Diabetes With Chronic Kidney Disease: FLOW Trial Cardiovascular Subgroup Analyses. PMID 42233552 · DOI 10.1016/j.jacc.2026.02.5125 · matched on "Semaglutide" | human-rct | — | none stated | 2026-06-02 |
| HUMAN-TRIAL | Oral semaglutide reduces diabetes-related distress in adults with type 2 diabetes mellitus switching from DPP-4 inhibitors. The DOORS prospective real-world Italian study. PMID 41951127 · DOI 10.1016/j.diabres.2026.113244 · matched on "Semaglutide" | human-observational | — | none stated | 2026-06-01 |
| HUMAN-TRIAL | Real-world impact of oral semaglutide on inflammatory markers in patients at high cardiovascular risk. PMID 42061608 · DOI 10.1016/j.rceng.2026.502562 · matched on "Semaglutide" | human-observational | — | none stated | 2026-06-01 |
| HUMAN-TRIAL | Semaglutide Effects on Insulin Sensitivity and beta-Cell Function in Patients With Schizophrenia, Prediabetes, and Obesity Treated With Second-Generation Antipsychotics: Findings From the HISTORI Trial, a 30-Week Randomized, Placebo-Controlled Trial With Semaglutide 1.0 mg Weekly. PMID 41778920 · DOI 10.2337/dc25-2041 · matched on "Semaglutide" | human-rct | — | none stated | 2026-05-01 |
| HUMAN-TRIAL | Dose-Escalation Regimens for Incretin Mimetics in Type 2 Diabetes Are Associated With Tolerance for Nausea and Vomiting. PMID 41757397 · DOI 10.1111/dom.70613 · matched on "Semaglutide" | human-rct | — | none stated | 2026-05-01 |
| HUMAN-TRIAL | Comparative real-world outcomes of tirzepatide vs semaglutide in patients with obesity and type2 diabetes: A retrospective propensity-matched cohort study. PMID 42376874 · DOI 10.1177/14791641261465360 · matched on "Semaglutide" | human-observational | — | none stated | 2026-05-01 |
| HUMAN-TRIAL | Oral Semaglutide and Change in Cardiovascular Risk Factors in High-Risk Type 2 Diabetes: A Post Hoc Secondary Analysis of the SOUL Randomized Clinical Trial. PMID 41879791 · DOI 10.1001/jamacardio.2026.0245 · matched on "Semaglutide" | human-rct | — | none stated | 2026-05-01 |
| HUMAN-TRIAL | Inpatient safety, effectiveness of SGLT2 inhibitors and GLP-1 RAs in type 2 diabetes: ENDOCARE, a pragmatic prospective cohort study. PMID 41913157 · DOI 10.1186/s12933-026-03156-6 · matched on "Semaglutide" | human-observational | — | none stated | 2026-03-30 |
| HUMAN-TRIAL | Bispecific GLP-1/GLP-2 agonism in advanced type 2 diabetes: preclinical characterization and a randomized, double-blind, placebo-controlled phase I trial. PMID 41876542 · DOI 10.1038/s41467-026-71080-0 · matched on "Semaglutide" | human-rct | — | none stated | 2026-03-24 |
| HUMAN-TRIAL | Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIEVE-3): a multinational, multicentre, non-inferiority, open-label, randomised, phase 3 trial. PMID 41765029 · DOI 10.1016/s0140-6736(26)00202-3 · matched on "Semaglutide" | human-rct | — | none stated | 2026-03-21 |
| HUMAN-TRIAL | Patients after acute myocardial infarction: potential of semaglutide in prognosis for reducing events and mortality. PMID 41520703 · DOI 10.1016/j.rceng.2026.502455 · matched on "semaglutida" | human-observational | — | none stated | 2026-02-01 |
| HUMAN-TRIAL | Real-world glycemic control, exploratory cardiorenal indicators, and safety of polyethylene glycol loxenatide versus semaglutide in type 2 diabetes patients: a Chinese two-center retrospective cohort study. PMID 41953701 · DOI 10.3389/fendo.2026.1756581 · matched on "Semaglutide" | human-observational | — | none stated | 2026-01-01 |
| ANIMAL | Transcriptomics of S3 segment in mice: response to type 1 diabetes, SGLT1/2 inhibition, or GLP1 receptor agonism. PMID 42213650 · DOI 10.1152/ajprenal.00109.2026 · matched on "Semaglutide" | animal | — | none stated | 2026-07-01 |
| ANIMAL | Semaglutide Modulates Visceral Adipose Tissue Lipid Metabolism in Type 2 Diabetic Mice: A Lipidomics Study. PMID 42411489 · DOI 10.31083/fbl49873 · matched on "Semaglutide" | animal | — | none stated | 2026-06-22 |
| ANIMAL | Insulin and Incretin Receptor Agonists Reciprocally Alter Their Blood-Brain Barrier Permeabilities. PMID 42196588 · DOI 10.3390/ijms27104611 · matched on "Semaglutide" | animal | — | none stated | 2026-05-21 |
| ANIMAL | Glycemia shifts pancreatic islet rhythmicity by influencing interactions between delta cells and alpha cells. PMID 41916313 · DOI 10.1016/j.cels.2026.101568 · matched on "Semaglutide" | animal | — | none stated | 2026-05-20 |
| ANIMAL | Optimized sublingual delivery of dual fatty acid-conjugated GLP-1 receptor agonist TE-8105 produces durable efficacy in diabetic mice. PMID 41819389 · DOI 10.1016/j.ijpharm.2026.126752 · matched on "Semaglutide" | animal | — | none stated | 2026-04-10 |
| ANIMAL | Early intervention with tirzepatide or semaglutide influences anti-atherosclerotic effects in ApoE knockout mice. PMID 41946762 · DOI 10.1038/s41598-026-42437-8 · matched on "Semaglutide" | animal | — | none stated | 2026-04-07 |
| ANIMAL | Complementary neuroprotective effects of semaglutide and papaya in diabetic encephalopathy via antioxidant and insulin-signaling pathways. PMID 41792420 · DOI 10.1038/s41598-026-42791-7 · matched on "Semaglutide" | animal | — | none stated | 2026-03-06 |
| PRECLINICAL | GLP-1 receptor agonists in pediatric obesity and diabetes: a systematic review of efficacy, metabolic effects, and safety. PMID 42365860 · DOI 10.1016/j.diabres.2026.113400 · matched on "Semaglutide" | not determined | 901 | none stated | 2026-08-01 |
| PRECLINICAL | Semaglutide versus GLP-1 agonists. Effectiveness, safety, and quality of life in patients with diabetes mellitus 2. The SEVERAL study. PMID 36520578 · matched on "semaglutida" | not determined | 360 | none stated | 2022-08-30 |
| PRECLINICAL | Annual pharmacy cost per patient achieving composite treatment endpoints: a cost to target analysis of tirzepatide versus subcutaneous semaglutide 1 mg in patients with type 2 diabetes in the UK. PMID 41771166 · DOI 10.1080/13696998.2026.2631920 · matched on "Semaglutide" | not determined | — | none stated | 2026-12-01 |
| PRECLINICAL | GLP-1 receptor agonists in stroke prevention: a narrative review on emerging therapeutic frontiers. PMID 41999297 · DOI 10.1080/07853890.2026.2660386 · matched on "Semaglutide" | not determined | — | none stated | 2026-12-01 |
| PRECLINICAL | Hydrophobic ion pairing formed semaglutide designed for oral self-microemulsifying delivery in diabetes treatment. PMID 42349668 · DOI 10.1016/j.ejpb.2026.115167 · matched on "Semaglutide" | not determined | — | none stated | 2026-09-01 |
| PRECLINICAL | Depressed mood and suicidal thoughts reporting with GLP-1 receptor agonists in type 2 diabetes: A WHO VigiBase study. PMID 42002107 · DOI 10.1016/j.jad.2026.121802 · matched on "Semaglutide" | not determined | — | none stated | 2026-08-15 |
| PRECLINICAL | 1-year outcomes of semaglutide, tirzepatide, and sleeve gastrectomy in obesity in type 2 diabetes: a retrospective cohort study. PMID 42309121 · DOI 10.1016/s2213-8587(26)00030-6 · matched on "Semaglutide" | not determined | — | none stated | 2026-08-01 |
| PRECLINICAL | Dulaglutide-associated body odor with dechallenge and rechallenge in a patient with type 2 diabetes. PMID 42087771 · DOI 10.5414/cp204985 · matched on "Semaglutide" | not determined | — | none stated | 2026-08-01 |
| PRECLINICAL | Glucagon-Like Peptide-1 Receptor Agonists and the Risk of Non-Arteritic Anterior Ischemic Optic Neuropathy: A Consensus Statement by the North American Neuro-Ophthalmology Society and the American Academy of Ophthalmology. PMID 42132708 · DOI 10.1016/j.ophtha.2026.04.008 · matched on "Semaglutide" | not determined | — | none stated | 2026-08-01 |