| HUMAN-TRIAL | evidence | Comparison of lifestyle, surgery, and semaglutide for weight management in endometrial cancer: a prospective observational study. | Semaglutide | Weight & fat loss · human-observational | 2026-12-01 |
| HUMAN-TRIAL | evidence | Cost-effectiveness of tirzepatide versus semaglutide for patients with obesity or overweight in the US: evidence from the SURMOUNT-5 head-to-head phase-3 trial. | Wegovy | Weight & fat loss · human-observational | 2026-12-01 |
| HUMAN-TRIAL | evidence | Evaluation of the Safety, Efficacy and Pharmacokinetics of BGM0504 in Chinese Adults With Type 2 Diabetes: A Multicentre, Randomised, Controlled and Double-Blind Phase II Trial. | Semaglutide | Glycemic control · human-rct | 2026-08-01 |
| HUMAN-TRIAL | evidence | The impact of automated insulin delivery on glucose management in people with diabetes and advanced chronic kidney disease. | Semaglutide | Glycemic control · human-rct | 2026-08-01 |
| HUMAN-TRIAL | evidence | Multi-Parametric Magnetic Resonance Imaging to Assess Empagliflozin Effect on the Kidneys in People With Type 2 Diabetes Mellitus: A Pilot Clinical Trial. | Semaglutide | Glycemic control · human-rct | 2026-08-01 |
| HUMAN-TRIAL | evidence | Efficacy and safety of once-weekly cagrilintide-semaglutide (CagriSema) in adults with type 2 diabetes inadequately controlled on diet and exercise (REIMAGINE 1): a randomised, double-blind, placebo-controlled, phase 3a study. | Semaglutide | Glycemic control · human-rct · n = 189 | 2026-08-01 |
| HUMAN-TRIAL | evidence | Association of GLP-1 receptor agonists with alcohol use disorder-related and substance use disorder-related hospital admissions during treatment and after discontinuation: a Swedish register-based within-individual observational study. | Semaglutide | Glycemic control · human-observational | 2026-08-01 |
| HUMAN-TRIAL | evidence | Implementation of the IWQOL-Lite-CT in Observational Research: Comparison of Baseline Scores With a Clinical Trial Population and Psychometric Evaluation. | Semaglutide | Weight & fat loss · human-observational | 2026-08-01 |
| HUMAN-TRIAL | evidence | Cagrilintide-semaglutide (CagriSema) versus semaglutide or cagrilintide in people with type 2 diabetes (REIMAGINE 2): a double-blind, randomised, controlled, phase 3 study. | Semaglutide | Glycemic control · human-rct | 2026-08-01 |
| HUMAN-TRIAL | evidence | Semaglutide 25 mg Oral Versus Semaglutide 2.4 mg Injectable: An Indirect Treatment Comparison of Weight Loss Outcomes. | Semaglutide | Weight & fat loss · human-rct | 2026-08-01 |
| HUMAN-TRIAL | evidence | Semaglutide Injection in Indian Patients With Type 2 Diabetes Mellitus: A Randomised, Phase III, Active-Controlled Study. | Ozempic | Glycemic control · human-rct | 2026-08-01 |
| HUMAN-TRIAL | evidence | Glucagon-Like Peptide-1 Receptor Agonists and Risk of Systemic and Ocular Vascular Complications in Patients With Type 2 Diabetes and Diabetic Retinopathy. | Semaglutide | Glycemic control · human-observational · n = 173216 | 2026-08-01 |
| HUMAN-TRIAL | evidence | Cagrilintide-semaglutide (CagriSema) as an add-on to basal insulin in adults with type 2 diabetes (REIMAGINE 3): a randomised, double-blind, placebo-controlled, multicentre, phase 3 study. | Semaglutide | Glycemic control · human-rct | 2026-07-04 |
| HUMAN-TRIAL | evidence | Differential Impact of Metabolic Bariatric Surgery Versus Semaglutide on Adverse Hepatic and Extrahepatic Outcomes in Individuals With Metabolic Dysfunction-Associated Steatotic Liver Disease and Type 2 Diabetes. | Semaglutide | Glycemic control · human-observational | 2026-07-01 |
| HUMAN-TRIAL | evidence | Semaglutide and Effort-Based Decision-Making in Major Depressive Disorder: A Randomized Clinical Trial. | Semaglutide | Mood & anxiety · human-rct · n = 72 | 2026-07-01 |
| HUMAN-TRIAL | evidence | Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial. | Semaglutide | Weight & fat loss · human-rct | 2026-07-01 |
| HUMAN-TRIAL | evidence | Short-term comparative effects of semaglutide, either alone or in conjunction with canagliflozin, on early diabetic kidney disease. | Semaglutide | Glycemic control · human-rct | 2026-07-01 |
| HUMAN-TRIAL | evidence | Effects of a 6-week subcutaneous infusion of native GIP alone or as add-on to semaglutide in people with type 2 diabetes: a single-centre, double-blind, parallel-group, randomised, placebo-controlled trial. | Semaglutide | Glycemic control · human-rct | 2026-07-01 |
| HUMAN-TRIAL | evidence | Semaglutide versus placebo in individuals with poor weight loss after bariatric surgery: a double-blinded, randomized, placebo-controlled trial. | Semaglutide | Weight & fat loss · human-rct | 2026-07-01 |
| HUMAN-TRIAL | evidence | Relationship of early rapid weight loss to efficacy and safety of tirzepatide and semaglutide for obesity: SURMOUNT-5 post hoc analysis. | Semaglutide | Weight & fat loss · human-rct | 2026-07-01 |
| HUMAN-TRIAL | evidence | Semaglutide Treatment in Young Adults Living With Type 2 Diabetes: A Post Hoc Analysis From the SUSTAIN and PIONEER Clinical Trials. | Semaglutide | Glycemic control · human-rct | 2026-07-01 |
| HUMAN-TRIAL | evidence | Cardiometabolic and Renal Outcomes in Semaglutide Users with Type 2 Diabetes Achieving Glycemic and Weight Goals: An Observational Cohort Study. | Semaglutide | Glycemic control · human-observational | 2026-07-01 |
| HUMAN-TRIAL | evidence | Early Adjuvant Treatment with Semaglutide After Sleeve Gastrectomy in Patients with Class II-III Obesity: A Prospective Non-Randomized Controlled Study. | Semaglutide | Weight & fat loss · human-observational | 2026-07-01 |
| HUMAN-TRIAL | evidence | Effects of Semaglutide on Body Composition and GFR: A Prespecified Analysis of the SMART Trial. | Semaglutide | Weight & fat loss · human-rct | 2026-07-01 |
| HUMAN-TRIAL | evidence | Renal or Hepatic Impairment Does Not Affect Pharmacokinetics, Safety, or Tolerability of Subcutaneous Cagrilintide. | Semaglutide | Glycemic control · human-rct | 2026-07-01 |
| HUMAN-TRIAL | evidence | Ischemic optic neuropathy with semaglutide: global observational analysis of sex- and formulation-specific risk. | Ozempic | Glycemic control · human-observational | 2026-06-22 |
| HUMAN-TRIAL | evidence | Elecoglipron, an oral small molecule GLP-1 receptor agonist in adults with type 2 diabetes (SOLSTICE): a multicentre, phase 2b, randomised, placebo-controlled trial. | Semaglutide | Glycemic control · human-rct | 2026-06-20 |
| HUMAN-TRIAL | evidence | Kidney and Survival Benefits of Semaglutide in Diabetes With Chronic Kidney Disease: FLOW Trial Cardiovascular Subgroup Analyses. | Semaglutide | Glycemic control · human-rct | 2026-06-02 |
| HUMAN-TRIAL | evidence | Emulated Effects of Glucagon-Like Peptide 1 Receptor Agonist Therapy in the General Population. | Semaglutide | human-rct | 2026-06-02 |
| HUMAN-TRIAL | evidence | Combining GLP-1 Receptor Agonists and Health-Behaviour and Lifestyle Therapy Yields Higher Adherence and Reduces Session Needs for Successful Weight Management in Adolescence: An Observational Real-World Single-Center Study. | Semaglutide | Weight & fat loss · human-observational | 2026-06-01 |
| HUMAN-TRIAL | evidence | SEMASEARCH Study Design: Real-World Evaluation of Semaglutide 2.4 mg in Adults With Severe Obesity Underrepresented in Clinical Trials. | Semaglutide | Weight & fat loss · human-observational | 2026-06-01 |
| HUMAN-TRIAL | evidence | Preoperative GLP-1 Receptor Agonists and Thromboinflammatory Markers in Patients Undergoing Abdominoplasty: A Prospective Monocentric Study. | Semaglutide | Weight & fat loss · human-observational | 2026-06-01 |
| HUMAN-TRIAL | evidence | Real-world weight loss with injectable semaglutide vs dulaglutide for diabetes. | Ozempic | Glycemic control · human-observational · n = 120 | 2026-06-01 |
| HUMAN-TRIAL | evidence | Real-world impact of oral semaglutide on inflammatory markers in patients at high cardiovascular risk. | Semaglutide | Glycemic control · human-observational | 2026-06-01 |
| HUMAN-TRIAL | evidence | Patient-Reported Adverse Events with Adjunctive Tirzepatide or Semaglutide Treatment in Adults with Type 1 Diabetes. | Semaglutide | Glycemic control · human-observational · n = 230 | 2026-06-01 |
| HUMAN-TRIAL | evidence | Oral semaglutide reduces diabetes-related distress in adults with type 2 diabetes mellitus switching from DPP-4 inhibitors. The DOORS prospective real-world Italian study. | Semaglutide | Glycemic control · human-observational | 2026-06-01 |
| HUMAN-TRIAL | evidence | Efficacy, Safety and Pharmacokinetics of Semaglutide 1.7 mg for Obesity Treatment in Adolescents: A Model-Informed Drug Development Approach. | Wegovy | Weight & fat loss · human-rct | 2026-06-01 |
| HUMAN-TRIAL | evidence | Efficacy and safety of co-administered cagrilintide and semaglutide versus semaglutide alone in adults with overweight or obesity with or without type 2 diabetes in Japan and Taiwan (REDEFINE 5): a multicentre, randomised, active-controlled, phase 3a trial. | Semaglutide | human-rct | 2026-06-01 |
| HUMAN-TRIAL | evidence | Real-world use of semaglutide for obesity treatment: A cohort study in an integrated health care delivery system. | Semaglutide | Weight & fat loss · human-observational | 2026-06-01 |
| HUMAN-TRIAL | evidence | Efficacy and safety of oral semaglutide 14 mg (flexible dose) in early-stage symptomatic Alzheimer's disease (evoke and evoke+): two phase 3, randomised, placebo-controlled trials. | Semaglutide | Cognition & memory · human-rct · n = 3808 | 2026-05-30 |
| HUMAN-TRIAL | evidence | Semaglutide slows epigenetic aging in a randomized trial of HIV-associated lipohypertrophy. | Semaglutide | Longevity & cellular aging · human-rct · n = 84 | 2026-05-19 |
| HUMAN-TRIAL | evidence | Glucagon-like peptide-1 receptor agonists in patients with heart failure with reduced ejection fraction. | Semaglutide | Lipid & cardiovascular markers · human-observational · n = 127021 | 2026-05-05 |
| HUMAN-TRIAL | evidence | Once-weekly semaglutide versus placebo in patients with alcohol use disorder and comorbid obesity: a randomised, double-blind, placebo-controlled trial. | Semaglutide | human-rct | 2026-05-02 |
| HUMAN-TRIAL | evidence | Tirzepatide versus semaglutide for the prevention of mild cognitive impairment, dementia, and Alzheimer's disease in type 2 diabetes: A real-world, retrospective cohort study. | Semaglutide | Cognition & memory · human-observational | 2026-05-01 |
| HUMAN-TRIAL | evidence | Semaglutide Effects on Insulin Sensitivity and beta-Cell Function in Patients With Schizophrenia, Prediabetes, and Obesity Treated With Second-Generation Antipsychotics: Findings From the HISTORI Trial, a 30-Week Randomized, Placebo-Controlled Trial With Semaglutide 1.0 mg Weekly. | Semaglutide | Glycemic control · human-rct | 2026-05-01 |
| HUMAN-TRIAL | evidence | Comparative real-world outcomes of tirzepatide vs semaglutide in patients with obesity and type2 diabetes: A retrospective propensity-matched cohort study. | Semaglutide | Glycemic control · human-observational | 2026-05-01 |
| HUMAN-TRIAL | evidence | Oral Semaglutide and Change in Cardiovascular Risk Factors in High-Risk Type 2 Diabetes: A Post Hoc Secondary Analysis of the SOUL Randomized Clinical Trial. | Semaglutide | Glycemic control · human-rct | 2026-05-01 |
| HUMAN-TRIAL | evidence | Muscle atrophy associated with glucagon-like Peptide-1 receptor agonists: A population-based observational study. | Semaglutide | human-observational | 2026-05-01 |
| HUMAN-TRIAL | evidence | Dose-Escalation Regimens for Incretin Mimetics in Type 2 Diabetes Are Associated With Tolerance for Nausea and Vomiting. | Semaglutide | Glycemic control · human-rct | 2026-05-01 |
| HUMAN-TRIAL | evidence | Semaglutide on liver fibrosis and heart outcomes in patients at high risk of liver fibrosis: a prespecified analysis of the SELECT randomized trial. | Semaglutide | human-rct | 2026-05-01 |