| INDEPENDENT-REVIEW | review | Switched from semaglutide to compounded tirzepatide four months ago, longer write up for anyone considering it
Semaglutide worked for me, I want to be upfront about that before getting into why I switched. Seven months on it, lost around 22 pounds, and the appetite suppression was real enough that I stopped thinking about food in the way I used to. The problem showed up around month five when the | COMMUNITY | — | 2026-05-09 |
| INDEPENDENT-REVIEW | review | Switched from semaglutide to compounded tirzepatide four months ago, longer write up for anyone considering it
Semaglutide worked for me, I want to be upfront about that before getting into why I switched. Seven months on it, lost around 22 pounds, and the appetite suppression was real enough that I stopped thinking about food in the way I used to. The problem showed up around month five when the | COMMUNITY | — | 2026-05-09 |
| INDEPENDENT-REVIEW | review | Was skeptical about compounded semaglutide but here's what changed my mind after 3 months
I'll be honest i spent way too long overthinking this. The FDA drama, the compounding pharmacy stuff, the horror stories online. It paralyzed me for a while.
What finally helped was finding a provider that actually explained the whole stack, what compounding means, what 503a vs 503b is, what's actually in | COMMUNITY | — | 2026-05-09 |
| INDEPENDENT-REVIEW | review | I started on .25 mg of compounded semaglutide for a month and got some good results. Less food noise and impulses. Couldn’t eat half as much without feeling full or a little queasy. Some heartburn and very slight nausea at times. A little constipation but overall not bad. Lost about 7-9 lbs. the first month decided I could handle more and asked for an increase in dose and they got me .375 mg | COMMUNITY | — | 2026-05-08 |
| INDEPENDENT-REVIEW | review | Anyone lose more than 100 lbs with the help of semaglutide?
I’m looking to hear about people’s personal experiences losing a large amount of weight with semaglutide. About of stories have people losing 50 or 75 lbs but how about folks who’ve lost 100 or 150 lbs or more. How long did it take? What were some of the challenges? Did anything surprise you about your experience? Have you maintained a | COMMUNITY | — | 2026-05-07 |
| INDEPENDENT-REVIEW | review | What glp1? Semaglutide? Tirzepatide? Retatrutide?
Note to people, glp2 and glp3 are not a thing. You can have glp1 agonists that act on other receptors.
Let's not normalize the nonsensical codewords created by grey market advertising. | COMMUNITY | — | 2026-05-07 |
| INDEPENDENT-REVIEW | review | I’ve been safer on Reta than semaglutide which made me VERY ill | COMMUNITY | — | 2026-05-05 |
| INDEPENDENT-REVIEW | review | Ha. Good question. And the answer would have to be no, as we have significant real world human data from semaglutide and tirzepatide. | COMMUNITY | — | 2026-05-05 |
| INDEPENDENT-REVIEW | review | Myth: Retatrutide is 'just a stronger semaglutide' — the triple agonist mechanism tells a different story
[removed] | COMMUNITY | — | 2026-05-05 |
| INDEPENDENT-REVIEW | review | Key Differences of Retatrutide, Tirzepatide, Semaglutide & Mazdutide. | COMMUNITY | — | 2026-05-03 |
| INDEPENDENT-REVIEW | review | Semaglutide or Tri
I have been on a compounded version of Semi since October 2025, with a month break in January. I have lost 20 pounds. I stared on 10 mil and now I am on 50. I have to renew my order and don’t know if I should increase my dose, stay the same or switch to Trizepatide. If I switch to Tri I know I will have to start at a lower dose. I feel like 20 pounds in over 6 months is not a | COMMUNITY | — | 2026-05-03 |
| INDEPENDENT-REVIEW | review | Canada Approved Generic Semaglutide
Hello! I live in the US. Just curious if anyone lives along the border and plans to drive across the border to buy the newly approved generic GLP1 in Canada?
If anyone has insight on the process (getting a prescription filled in Canada), that would be greatly appreciated. | COMMUNITY | — | 2026-05-02 |
| INDEPENDENT-REVIEW | review | Health Canada approves Apotex's semaglutide generic! | COMMUNITY | — | 2026-05-01 |
| INDEPENDENT-REVIEW | review | if you were prescribed, I assume you are obese and or diabetic. Semaglutide will decrease appetite more than anything else – that would be beneficial to you. | COMMUNITY | — | 2026-05-01 |
| INDEPENDENT-REVIEW | review | Honestly with the price for the prescription i might just skip the semaglutide | COMMUNITY | — | 2026-04-30 |
| INDEPENDENT-REVIEW | review | Dr. Reddy's CEO: Another generics manufacturer likely to get semaglutide approval within a few weeks in Canada | COMMUNITY | — | 2026-04-29 |
| INDEPENDENT-REVIEW | review | That’s not really the right conclusion. Yes, injected sermorelin/GHRH studies can show IGF-1 increases in that general range, but that’s at the group level, across multiple subjects, which helps average out natural IGF-1 noise. It does not mean a 20% increase in one person proves the drug worked.
With n=1, a 20% IGF-1 change is still completely compatible with normal repeat-test | COMMUNITY | — | 2026-04-29 |
| INDEPENDENT-REVIEW | review | Thanks for posting to r/semaglutide!
A brief reminder about our rules. We do not permit the discussion of non-FDA approved formulations of semaglutide, nor do we permit selling or offering for sale any medication, including by private message. Do not request or respond to a private message from anyone offering such, they are not endorsed by this sub.
If you’re just starting out, you may want to | COMMUNITY | — | 2026-04-28 |
| INDEPENDENT-REVIEW | review | I really think we have to stay on the meds to keep the weight off. I went on semaglutide 3 times. The first time for only 1 month and I ended up in the hospital with bad stomach issues.
Then about 6 months later I wanted to try it again but lower dose. That worked after months of using it. When I got to my weight goal, I stopped taking it and tried to eat right but my weight slowly started | COMMUNITY | — | 2026-04-28 |
| INDEPENDENT-REVIEW | review | Starting Semaglutide at a normal BMI
Hey everyone! I’m 5’2”, around 130 lbs, and about to start semaglutide. I’m mainly trying to lose about 10–12 lbs that I gained after a medical situation.
I also struggle with binge eating, so a big part of why I’m interested in this is the potential for the “food noise” to quiet down.
I’d love to hear from people who started semaglutide at a “normal” BMI, | COMMUNITY | — | 2026-04-28 |
| INDEPENDENT-REVIEW | review | Canada becomes the first G7 country to approve a generic version of semaglutide | COMMUNITY | — | 2026-04-28 |
| INDEPENDENT-REVIEW | review | I'm at my goal & I haven't stopped my shots. It's been about 6 months. I try to eat higher calorie food so I don't keep losing. It can be tough because I'll get nauseous but I know who I am. I know I will gain it back. That's not a self fulfilling prophecy, it's truth. If I could keep it off myself I wouldn't have needed Semaglutide to start with. (Sometimes I take smaller doses too.) | COMMUNITY | — | 2026-04-28 |
| INDEPENDENT-REVIEW | review | Canada just approved its first generic semaglutide product. We are SO back!! | COMMUNITY | — | 2026-04-28 |
| INDEPENDENT-REVIEW | review | Canada approves first generic semaglutide product in Canada! We are SO back! | COMMUNITY | — | 2026-04-28 |
| INDEPENDENT-REVIEW | review | It’s not what you want to hear, but I’ve lost 100 and still look in the mirror and see the same person. We have been taught from birth that we are not good enough, and the ideals of what our brain thinks is “good” are unrealistic and usually impossible. In my experience, even when we try to logic our way into more appropriate goals, it’s nearly impossible to retrain that instinct feeling. I’ve | COMMUNITY | — | 2026-04-28 |
| INDEPENDENT-REVIEW | review | Since I don’t trust that you’ll know a reputable provider when you see one (sorry!) — stop by the “tirzepatidec0mpound” (but an O instead of a zero) sub and look for the pinned post called “Where to Buy.”
If you can’t find it, Google “Reddit tirzepatidec0mpound” but make the zero an O.
Those same providers also have semaglutide, in case you learn that’s the medication you are actually | COMMUNITY | — | 2026-04-28 |
| INDEPENDENT-REVIEW | review | I've been using OrderlyMeds since June 2024 and it's been the most affordable option l've found so far. They charge a flat monthly fee no matter the dose, which really helped once my dose went up. I was super skeptical of online providers at first, but l've had a good experience and support has been solid. If you use there spring code AMAT25 you can get three months of semaglutide for $66 a month | COMMUNITY | — | 2026-04-28 |
| INDEPENDENT-REVIEW | review | I will be starting Wegovy tomorrow (semaglutide) because I was worried about delaying treatment, but honestly the cost is pretty high for me long term. I’d ideally like to find a more affordable option for semaglutide if possible.
A couple questions:
Are there reputable/legit companies or programs you’ve used that offer semaglutide at a lower cost?
Has anyone switched from Wegovy to another | COMMUNITY | — | 2026-04-28 |
| INDEPENDENT-REVIEW | review | Switched straight from compounded semaglutide to Wegovy — how did it go?
Has anyone switched from compounded semaglutide (AgelessRx) to Wegovy without a break?
I’ve been using semaglutide through AgelessRx, but they recently stopped offering it and are switching me over to Wegovy 2.5 mg. My last semaglutide dose was last Wednesday, and I’m starting Wegovy without any gap in between.
I’m feeling | COMMUNITY | — | 2026-04-28 |
| INDEPENDENT-REVIEW | review | Question for anyone on Ozempic, semaglutide and other GLP-1 meds
Question for anyone on Ozempic, semaglutide and other GLP-1 meds: what surprised you most after starting?
I’m trying to separate hype from reality. Did it feel like a “miracle drug,” or more like a tool that still requires a lot of effort in the background?
Would appreciate honest experiences, especially about side effects and | COMMUNITY | — | 2026-04-28 |
| INDEPENDENT-REVIEW | review | the protein and fiber tracking point is spot on and honestly the most important thing on semaglutide. most people focus on calories when the real game changer is hitting 25 to 30g of fiber and at least 80 to 100g of protein daily. that combination is what keeps the nausea manageable and prevents the muscle loss that happens when you drop weight too fast on glp-1s. the challenge is that on | COMMUNITY | — | 2026-04-28 |
| INDEPENDENT-REVIEW | review | body aches on semaglutide are more common than people realize, especially in the first couple months. a few things that helped me: magnesium glycinate before bed (the glycinate form specifically, not oxide), and electrolyte packets beyond just water since you can be hydrated but still low on potassium and sodium.
also worth mentioning to your prescriber because sometimes adjusting the dose | COMMUNITY | — | 2026-04-28 |
| INDEPENDENT-REVIEW | review | Me too. Joint pain in my left hand. I'm eating anti inflammatory diet, taking curcumin and boswelia and omega 3 but nothing is helping. It only came on recently since I started semaglutide. I came on this site to see if anyone else had similar and apparently yes they do, although it's not an official reported side effect | COMMUNITY | — | 2026-04-28 |
| INDEPENDENT-REVIEW | review | Here’s my typical spiel with a few possibilities to get you started.
- Pomegranate Health is $249 for three months of semaglutide doses up to 1mg from Hallandale Pharmacy and $299 for three months of the highest doses. That’s $83 and $100 a month. They also have monthly and six-month packages as well as other pharmacy options. They serve all 50 states.
- Brello Health is $399 for three months | COMMUNITY | — | 2026-04-28 |
| INDEPENDENT-REVIEW | review | Compounded semaglutide
Hi all! I am maintaining my weight loss currently but my insurance will no longer cover any GLP-1's. I have been looking into paying out of pocket for compounded semaglutide but it is expensive and I am on a strict budget. Have you all found and been able to get compounded semaglutide at a decent price? I appreciate any help! | COMMUNITY | — | 2026-04-28 |
| INDEPENDENT-REVIEW | review | I have PCOS and just hormone issues as a whole. I lost slower on semaglutide, and it took what felt like forever.
Tirzeptide on the other hand has seemed to work faster for me and I found a few articles/studies about Tirz possibly working better for women with hormone issues and/or taking hormone replacement therapy. That may be why I have done better on it than Sema. | COMMUNITY | — | 2026-04-28 |
| INDEPENDENT-REVIEW | review | On day 5-7 of semaglutide when food noise returns, what should you eat?
[removed] | COMMUNITY | — | 2026-04-28 |
| INDEPENDENT-REVIEW | review | Only negative thing I have to say is depending on provider, you have to work your way up for it to be effective. I hate needles. I was on compounded semaglutide for 4 months about 2 years and lost 29 lbs. gained about 19 back. I started the pill this Jan but the provider, non insurance, made me start at the lowest dose and it did nothing. I went up each month for 3 months and nothing until i got | COMMUNITY | — | 2026-04-28 |
| INDEPENDENT-REVIEW | review | Has anyone here tried semaglutide in India? How did you get it prescribed? | COMMUNITY | — | 2026-04-28 |
| INDEPENDENT-REVIEW | review | The protein target on semaglutide is more important than most people realize
[removed] | COMMUNITY | — | 2026-04-28 |
| INDEPENDENT-REVIEW | review | When I first started I freaked out first shot but my doctor kinda helped with that because I’m on semaglutide and it puts a barrier over your heart and is good for your heart which eased up my panicking because anxiety it will have you thinking that your having a heart attack and mimic all the symptoms but it you panicking and anxiety will mimic things you think are happening when it’s not. To | COMMUNITY | — | 2026-04-28 |
| INDEPENDENT-REVIEW | review | Thank you ❤️ Reading these things really help me. My husband doesn't understand my anxiety at all. He thinks I should "just think of something else". It's good to hear from someone who understands that it's going to be okay and get better.
Did you have this reaction to semaglutide? | COMMUNITY | — | 2026-04-28 |
| INDEPENDENT-REVIEW | review | OP, this is good advice only after you've given semaglutide an actual chance ir side effects are too unbearable. By your posts, you've been on the lowest, starter dose. Some pepole do see lots of weight loss here, but the majority wont see much until they get up to the higher, therapeutic dosages (1.7mg, 2.4mg). As long as your side effects are tolerable the next best step is to go up in dose and | COMMUNITY | — | 2026-04-28 |
| INDEPENDENT-REVIEW | review | I’m 3 1/2 months in and lost 23 pounds already. My next jump in dosage will be to 1.7 dosage. Along with the semaglutide, diet and exercise are a big part of the weight loss. | COMMUNITY | — | 2026-04-28 |
| INDEPENDENT-REVIEW | review | I think it is a bit harsh to accuse OP of body dysmorphia. I started semaglutide looking similar to her before photo. It wasn’t what I had looked like for my entire life. I gained almost 60 lbs, it started when we went into lock down for covid, I didn’t work for a year, then I moved to Florida to be close to my parents because my dad had health complications, as he got better and I was looking | COMMUNITY | — | 2026-04-28 |
| INDEPENDENT-REVIEW | review | From what I've seen, building muscle on semaglutide is definitely possible but it tends to be slower and more dependent on consistency than anything else. Staying on top of resistance training and making protein a priority even when appetite is low seems to matter most, along with managing recovery since energy can dip during a deficit. I’ve also seen some people look into recovery support | COMMUNITY | — | 2026-04-27 |
| INDEPENDENT-REVIEW | review | Thanks for posting to r/semaglutide!
A brief reminder about our rules. We do not permit the discussion of non-FDA approved formulations of semaglutide, nor do we permit selling or offering for sale any medication, including by private message. Do not request or respond to a private message from anyone offering such, they are not endorsed by this sub.
If you’re just starting out, you may want to | COMMUNITY | — | 2026-04-27 |
| INDEPENDENT-REVIEW | review | I lost 60 pounds on Semaglutide, hit a plateau for almost 3 months. Switched to Tirzepatide and gained 5 pounds. Went back to Semaglutide and immediately lost 8 pounds. I had no side effects with either one. Everyone is definitely different in how they react! | COMMUNITY | — | 2026-04-27 |
| INDEPENDENT-REVIEW | review | I'll definitely look into it. I thought semaglutide was considered best for insulin resistance but everyone is different | COMMUNITY | — | 2026-04-27 |
| INDEPENDENT-REVIEW | review | Not really. Some people don’t really feel the positive effects until 1.7 or 2.4 mg. It sucks, but just keep putting one foot in front of the other. You can’t know if you are an actual non-responder to semaglutide until you’ve done 2.4mg for at least a month.
If you want to change it up from Southend Pharmacy meds, take a look at Pomegranate Health and their Hallandale Pharmacy option. I | COMMUNITY | — | 2026-04-27 |