| INDEPENDENT-REVIEW | review | My experience is that semaglutide is by far the strongest suppressant of cravings in general. | COMMUNITY | — | 2026-06-08 |
| INDEPENDENT-REVIEW | review | reta shoots up my heart rate (i think) should I try Tirezeptide or Semaglutide next for alcohol cravings?
Hey yall, I've been on reta for about 2 months now and I've lost about 30 pounds, and I've successfully quit alcohol. I was consuming alchol daily, and had a physical dependence for about 2 months that was destroying my finances, mental health, grades, performance, and relationships which has | COMMUNITY | — | 2026-06-08 |
| INDEPENDENT-REVIEW | review | Semaglutide
im switching from capsules to injectables. HOW DO I DO ITTTT | COMMUNITY | — | 2026-06-07 |
| INDEPENDENT-REVIEW | review | Generic semaglutide through Felix (Canada)
[removed] | COMMUNITY | — | 2026-06-06 |
| INDEPENDENT-REVIEW | review | Gallstones due to semaglutide ?
Have any of you developed gallstones since you started taking Ozempic?
I’ve had stomach problems for a very long time, so I get checked out often. Two years ago, I had a liver ultrasound, and everything looked fine.
But two months after starting Ozempic, I had a severe attack of cholecystitis. I went to the hospital and will eventually need surgery.
In the | COMMUNITY | — | 2026-06-06 |
| INDEPENDENT-REVIEW | review | Switched from Wegovy Pill to compound Semaglutide
I was on the starter dose for the pill for a month and then 3 weeks ago I switched to the vial compound at .25 mg. I haven’t lost any weight since I switched, I’m wondering if anyone had that experience? Could it be because the dose is lower than the starter for the pill? | COMMUNITY | — | 2026-06-04 |
| INDEPENDENT-REVIEW | review | Is compounded semaglutide actually safe and legal?
My insurance just denied my Wegovy coverage completely, and someone suggested looking into compounded semaglutide instead. I'm a bit nervous though—is this actually legal, and how do you make sure the pharmacy making it is safe and legitimate? | COMMUNITY | — | 2026-06-02 |
| INDEPENDENT-REVIEW | review | How do I get prescription semaglutide in India?
Hi. I'm 21M, 108kgs, BMI 32.6.
I saw a massive weight gain ever since I started psychiatric medication at 17. I tried dieting and gym multiple times but I see no change in my body or weight. In fact, I'm not even eating more than I did before I started my meds. I've been to multiple doctors and they suspect my meds are causing the weight gain.
I | COMMUNITY | — | 2026-06-01 |
| INDEPENDENT-REVIEW | review | Tirzepatide vs semaglutide, what I've read and what seems to actually matte
This comparison comes up constantly so here's my attempt at a clear-headed take based on the actual data.
Mechanism: semaglutide is a GLP-1 receptor agonist. Tirzepatide activates both GLP-1 and GIP receptors. The dual agonism is why the weight loss outcomes differ. GIP receptor activation appears to amplify the | COMMUNITY | — | 2026-05-30 |
| INDEPENDENT-REVIEW | review | Yes i did. Semaglutide just slowed gastric emptying but did nothing for food drive. Tirz combined less food drive and slower gastric emptying. Reta feels like a completely different animal altogether. | COMMUNITY | — | 2026-05-30 |
| INDEPENDENT-REVIEW | review | Retatrutide is known for having little appetite suppresison compared to semaglutide or tirzepatide.... In particular with such low levels that are about the same as endogen production. | COMMUNITY | — | 2026-05-29 |
| INDEPENDENT-REVIEW | review | there is ongoing research using tirzepatide and semaglutide in OUD and other addictions. | COMMUNITY | — | 2026-05-28 |
| INDEPENDENT-REVIEW | review | Switching from Ozempic to compounded semaglutide and worried about the dose handoff
On Ozempic 1.5mg for 14 months. Was on 1mg before that for 4 months. Total 18 months on therapy and the weight loss has been steady, currently at 38 lbs down from where I started.
Coverage changing in 30 days because my employer is restructuring our pharmacy benefit. Ozempic moves to a tier where my copay | COMMUNITY | — | 2026-05-27 |
| INDEPENDENT-REVIEW | review | Switching from Ozempic to compounded semaglutide and worried about the dose handoff
On Ozempic 1.5mg for 14 months. Was on 1mg before that for 4 months. Total 18 months on therapy and the weight loss has been steady, currently at 38 lbs down from where I started.
Coverage changing in 30 days because my employer is restructuring our pharmacy benefit. Ozempic moves to a tier where my copay would | COMMUNITY | — | 2026-05-27 |
| INDEPENDENT-REVIEW | review | Shoppers Drug Mart is straight up gaslighting Canadian patients about the new generic semaglutide
I’m convinced my local Shoppers Drug Mart is actively trying to scam patients into buying expensive, brand name Wegovy instead of the new, generic semaglutide that just hit the Canadian market. I’m posting this so you guys don’t get played
I called my local Shoppers today to see if they had the | COMMUNITY | — | 2026-05-27 |
| INDEPENDENT-REVIEW | review | Swapping to a generic semaglutide next week.
Was curious about everyone’s results (everyone is different of course) on the generic brand versus Wegovy? | COMMUNITY | — | 2026-05-25 |
| INDEPENDENT-REVIEW | review | 14 weeks on semaglutide, my breakdown if anybody is interested in the data :)
Wanted to do a proper breakdown since I've been logging everything and the data is actually interesting to look back on. (Ignore the Week 1 on the screenshot, i accidently reset it)
Starting weight: 181.4 lbs Current: 162.0 lbs Total lost: 19.4 lbs over 14 weeks.
Week by week rough breakdown:
Weeks 1–2: down about 4 | COMMUNITY | — | 2026-05-25 |
| INDEPENDENT-REVIEW | review | Been on Wegovy 18 months and considering compounded semaglutide for cost reasons but worried about maintenance
Mom of 3, on Wegovy 18 months at 1.7mg maintenance. Lost 47 lbs total, holding steady for the last 5 months at goal weight. Genuinely the best thing I've done for my health in years and the maintenance phase has been working.
Employer is changing benefits in 60 days and Wegovy is | COMMUNITY | — | 2026-05-25 |
| INDEPENDENT-REVIEW | review | Semaglutide becoming less effective over time?
Been in semaglutide for just about two years. Went from maximum 225 pounds to lowest 175. Definitely very happy with the results.
Started on .25mg, which was very effective in curbing hunger and cravings. I started losing weight immediately and quickly. After the second month, went up to .5mg, stayed there for a long time and then finally went to | COMMUNITY | — | 2026-05-24 |
| INDEPENDENT-REVIEW | review | Anyone transitioned from Ozempic to compounded semaglutide?
Looking for result comparisons from people who have transitioned. Lost insurance and can’t afford to go cash pay to continue on Oz. I’ve signed up for a compounded vial and plan to start it once my last few doses are gone. What can I expect? Are side effects the same? Weight loss? | COMMUNITY | — | 2026-05-23 |
| INDEPENDENT-REVIEW | review | a few business days. ive taken their semaglutide before and it seemed to work | COMMUNITY | — | 2026-05-23 |
| INDEPENDENT-REVIEW | review | Semaglutide is the only one that makes me drink less because i feel too physically full to drink beer. Liquor still works but I only buy beer for that reason. | COMMUNITY | — | 2026-05-22 |
| INDEPENDENT-REVIEW | review | Canada - generic semaglutide cost just for prescription?
Hi All,
Has anyone tried to fill their generic prescriptions at Costco or another pharmacy? If so, what price are you paying (as well as your dose)? | COMMUNITY | — | 2026-05-22 |
| INDEPENDENT-REVIEW | review | Has anyone here used Wegovy (Semaglutide) for weight loss long-term?
I’ve been researching Wegovy for weight loss and wanted to hear real experiences from people who have actually used it for a few months or longer. Did it mainly help with appetite control, cravings, or overall calorie intake? Also curious about side effects, energy levels, and whether the weight stayed off after some time.
I’m | COMMUNITY | — | 2026-05-22 |
| INDEPENDENT-REVIEW | review | Semaglutide – new price & ordering from Felix in Canada 🇨🇦
I'm soo happy there’s finally a generic semaglutide option in Canada 😭
I’ve been on Ozempic for the past year and it’s helped me lose about 45 lbs (starting weight of 215lbs), but now that there's a lower cost option I'm switching to a generic semaglutide. Price is $150 now... I’ve been maintaining for a bit now and was already | COMMUNITY | — | 2026-05-22 |
| INDEPENDENT-REVIEW | review | Canada now has generic semaglutide at $149 CAD/month — interview with Felix Health's Chief Pharmacy Officer about the Apotex partnership
[removed] | COMMUNITY | — | 2026-05-21 |
| INDEPENDENT-REVIEW | review | The molecular weight of GLP1 agonists is too high to effectively absorb through any of those routes and oral is a poor route for peptides in general because they rarely survive the stomach. Consider oral semaglutide - people work their way up to a max dose 25 mg/day vs a couple mg/week for subq | COMMUNITY | — | 2026-05-21 |
| INDEPENDENT-REVIEW | review | tirzepatide or semaglutide, and why?
[removed] | COMMUNITY | — | 2026-05-21 |
| INDEPENDENT-REVIEW | review | Felix now has reduced cost on generic semaglutide! Did anyone else see this? | COMMUNITY | — | 2026-05-21 |
| INDEPENDENT-REVIEW | review | New generic semaglutide pricing from Felix in Canada
Just saw Felix dropped their Semaglutide pricing pretty hard... Ended up getting mine for $150/month and they waived the visit fee too. | COMMUNITY | — | 2026-05-21 |
| INDEPENDENT-REVIEW | review | Just got my script for Generic Semaglutide! Hopefully this works for me!
Been struggling with weight loss for years. Hopefully this helps me. | COMMUNITY | — | 2026-05-21 |
| INDEPENDENT-REVIEW | review | I just stated on it a month ago after taking a break from semaglutide. My energy is definitely up but it is just starting to kick in. | COMMUNITY | — | 2026-05-20 |
| INDEPENDENT-REVIEW | review | Dude posted earlier today freaking out over taking 20 units of semaglutide yesterday and another 30 units today. When converted to mg, total was 2.5mg 😭 | COMMUNITY | — | 2026-05-19 |
| INDEPENDENT-REVIEW | review | Calm down. You took total of 2.5mg, max dose used to be 2.4mg. FDA recently approved increased max dose of semaglutide to 7.2mg. You will be fine.
Just be more careful next time so you can avoid freaking out again. Maybe better labels or separate storage locations to prevent from repeating same mistake. | COMMUNITY | — | 2026-05-19 |
| INDEPENDENT-REVIEW | review | Lmao that’s not far off from a typical day with no semaglutide honestly | COMMUNITY | — | 2026-05-19 |
| INDEPENDENT-REVIEW | review | Are you sure? This seems like a LOT of semaglutide 😅 I’m gonna placebo effect my way into a panic attack. Should I skip next weeks dose? | COMMUNITY | — | 2026-05-19 |
| INDEPENDENT-REVIEW | review | Good to see somebody proving actual facts rather than just repeating the same stuff they’ve read on Reddit.
The reality is that it’s only the GLPs that move the dial. There’s a reason that almost nobody had heard of them before until Semaglutide made it mainstream. | COMMUNITY | — | 2026-05-18 |
| INDEPENDENT-REVIEW | review | Tesa will have a modest effect on energy expenditure because it elevates growth hormone. It also separately is a lipolytic which means it causes your body to break down lipids from fat tissue. But there’s problems. Tesa/GH also increases appetite enough to normally offset the energy expenditure increase, so it normally doesn’t cause any weight loss. Additionally while it does cause a shift in | COMMUNITY | — | 2026-05-18 |
| INDEPENDENT-REVIEW | review | Semaglutide —> Reta tips? | COMMUNITY | — | 2026-05-16 |
| INDEPENDENT-REVIEW | review | Getting started with Semaglutide in Canada
I am looking for advice about going on a generic semaglutide. I’m located in Canada and generics have just been approved and should become available shortly. I have not pursued a GLP-1 up until this point due to the cost, but I will be able to afford it now with the expected lower pricing. I’ve tried dieting many times over the years but I last a short | COMMUNITY | — | 2026-05-16 |
| INDEPENDENT-REVIEW | review | Yeah, a few, but the only one I’d take seriously right now is the GLP-1 category.
Semaglutide and tirzepatide seem to reduce cravings/reward-seeking for some people. Most of the stronger signal is around alcohol, but people also report less compulsive eating, nicotine cravings, impulse buying, etc. Not magic, but there’s enough human signal there that it’s worth paying attention to.
Oxytocin | COMMUNITY | — | 2026-05-15 |
| INDEPENDENT-REVIEW | review | Semaglutide helped me go from high functioning alcoholic to now maybe I have one drink a month and maybe less. | COMMUNITY | — | 2026-05-15 |
| INDEPENDENT-REVIEW | review | no. the third agonist in retatrutide stimulates metabolism. it was designed that way to mitigate some of the cramping and GI issues people get from semaglutide and tirzepatide. essentially balaning out the slowed digestion and prolonged fullness from the other agonists. | COMMUNITY | — | 2026-05-14 |
| INDEPENDENT-REVIEW | review | GHRP-2 and mk677 are both ghrelin agonists. Remove on or the other. Also at this point you could afford running HGH at 2IU daily, which has a lot more research behind it, it’s more predictable and overall better in most cases. As for semaglutide, there are better choices out there but if that is what you bought and it’s completely fine | COMMUNITY | — | 2026-05-14 |
| INDEPENDENT-REVIEW | review | Let's take some steps back. Primary indication for treatment with glp1 is diagnosis of diabetes. Not all who have diabetes are "fat" or eat a high sugar diet. Glp1s for weight loss, sleep apnea, pcos ect ect all secondary findings. I digress...a major risk factor for developing gastroperesis is diabetes.
"Kinda lost me here, Do you mean comparing GLP1s to other weight loss avenues like | COMMUNITY | — | 2026-05-14 |
| INDEPENDENT-REVIEW | review | i used to eat significantly more fiber and volume before. i eat more protein and less volume now, i optimize for iron
reta just does not slow down digestion as strongly as semaglutide
in my case, i’d argue that retatrutide helps nutrient absorption due to the slowing | COMMUNITY | — | 2026-05-14 |
| INDEPENDENT-REVIEW | review | The early concerns are that glp1 causes gastroparesis due to the slowing down of the gastric emptying
A widely cited and credible study is this 2023 research letter published in JAMA Network / JAMA:
https://jamanetwork.com/journals/jama/fullarticle/2810542
Risk of Gastrointestinal Adverse Events Associated With GLP-1 Receptor Agonists for Weight Loss
Key finding from the study:
* GLP-1 | COMMUNITY | — | 2026-05-14 |
| INDEPENDENT-REVIEW | review | Compound Semaglutide to Wegovy Pill?
Has anyone gone from a compound semaglutide to the Wegovy pill? I’m currently on 68 units of the compound weekly, and seeing great results. Down about 60 lbs since October 2025. I’m switching to the Wegovy pill at the rec of my PCP, starting at 1.5mg because she said it’s similar to 68 units. Would love to hear how the switch went for you! | COMMUNITY | — | 2026-05-12 |
| INDEPENDENT-REVIEW | review | Had some time to do some research. Novo Nordisk in 2018 and others since found that body weight actually DID affect semaglutide exposure (it was the only covariant to do so, in fact). Interestingly, though, they subsequently said that the variability stayed within a clinically acceptable range so there was no recommended adjustment to dosage. | COMMUNITY | — | 2026-05-11 |
| INDEPENDENT-REVIEW | review | Semaglutide
[removed] | COMMUNITY | — | 2026-05-11 |