| HUMAN-TRIAL | evidence | Muscle atrophy associated with glucagon-like Peptide-1 receptor agonists: A population-based observational study. | Semaglutide | human-observational | 2026-05-01 |
| HUMAN-TRIAL | evidence | Semaglutide on liver fibrosis and heart outcomes in patients at high risk of liver fibrosis: a prespecified analysis of the SELECT randomized trial. | Semaglutide | human-rct | 2026-05-01 |
| HUMAN-TRIAL | evidence | BMI response to dapagliflozin with or without semaglutide across obesity classes: a real-world observational study conducted in Saudi Arabia. | Semaglutide | Weight & fat loss · human-observational | 2026-05-01 |
| HUMAN-TRIAL | evidence | Toward Precision Obesity Pharmacotherapy: Using the Eating Behavior Phenotype Scale (EFCA) in Real-World Clinical Practice. | Semaglutide | Weight & fat loss · human-observational | 2026-04-30 |
| HUMAN-TRIAL | evidence | Comparison of Semaglutide and Lifestyle Counselling for Weight Loss Using Multi-Site Electronic Health Records. | Semaglutide | Weight & fat loss · human-observational | 2026-04-01 |
| HUMAN-TRIAL | evidence | Association between GLP-1 receptor agonist use and worsening mental illness in people with depression and anxiety in Sweden: a national cohort study. | Semaglutide | Mood & anxiety · human-observational · n = 95490 | 2026-04-01 |
| HUMAN-TRIAL | evidence | Real-world effectiveness of oral semaglutide on body weight, composition, and metabolic parameters in patients with obesity without diabetes. | semaglutida | Weight & fat loss · human-observational · n = 70 | 2026-04-01 |
| HUMAN-TRIAL | evidence | Simulated shared and supported decision making for amyloid immunotherapy in Alzheimer's disease: A bicentric study. | Semaglutide | Cognition & memory · human-observational · n = 25 | 2026-04-01 |
| HUMAN-TRIAL | evidence | Inpatient safety, effectiveness of SGLT2 inhibitors and GLP-1 RAs in type 2 diabetes: ENDOCARE, a pragmatic prospective cohort study. | Semaglutide | Glycemic control · human-observational | 2026-03-30 |
| HUMAN-TRIAL | evidence | Bispecific GLP-1/GLP-2 agonism in advanced type 2 diabetes: preclinical characterization and a randomized, double-blind, placebo-controlled phase I trial. | Semaglutide | Glycemic control · human-rct | 2026-03-24 |
| HUMAN-TRIAL | evidence | Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIEVE-3): a multinational, multicentre, non-inferiority, open-label, randomised, phase 3 trial. | Semaglutide | Glycemic control · human-rct | 2026-03-21 |
| HUMAN-TRIAL | evidence | Impact of oral semaglutide on quality of life and metabolic parameters in patients with type 2 diabetes mellitus: A multicenter observational study. | semaglutida | Glycemic control · human-observational · n = 43 | 2026-03-01 |
| HUMAN-TRIAL | evidence | Bimagrumab plus semaglutide alone or in combination for the treatment of obesity: a randomized phase 2 trial. | Semaglutide | Weight & fat loss · human-rct | 2026-03-01 |
| HUMAN-TRIAL | evidence | Preliminary Real-World Experience with Semaglutide in Obese Patients with Type 2 Diabetes on Chronic Hemodialysis: A Multicenter Pilot Study. | Semaglutide | human-observational | 2026-02-16 |
| HUMAN-TRIAL | evidence | Patients after acute myocardial infarction: potential of semaglutide in prognosis for reducing events and mortality. | semaglutida | Glycemic control · human-observational | 2026-02-01 |
| HUMAN-TRIAL | evidence | Fecal microbiome predicts treatment response after the initiation of semaglutide or empagliflozin uptake. | Ozempic | Glycemic control · human-observational | 2026-01-24 |
| HUMAN-TRIAL | evidence | Real-world glycemic control, exploratory cardiorenal indicators, and safety of polyethylene glycol loxenatide versus semaglutide in type 2 diabetes patients: a Chinese two-center retrospective cohort study. | Semaglutide | Glycemic control · human-observational | 2026-01-01 |
| HUMAN-TRIAL | evidence | Drug-induced gastric motility disorders: A disproportionality analysis from the FAERS and CVARD databases. | Semaglutide | Gut barrier & GI healing · human-observational | 2026-01-01 |
| HUMAN-TRIAL | evidence | Impact of semaglutide 2.4 mg on healthcare resource utilization and medical costs in patients with atherosclerotic cardiovascular disease in the United States (SHINE-ASCVD). | Wegovy | Weight & fat loss · human-observational | 2025-12-01 |
| HUMAN-TRIAL | evidence | Real-World Weight Loss Observed With Semaglutide and Tirzepatide in Patients with Overweight or Obesity and Without Type 2 Diabetes (SHAPE). | Wegovy | Weight & fat loss · human-observational · n = 9916 | 2025-11-01 |
| HUMAN-TRIAL | evidence | Semaglutide 2.4 mg Clinical Outcomes in Patients with Obesity or Overweight: A Real-World Retrospective Comparative Cohort Study. | Wegovy | Weight & fat loss · human-observational | 2025-10-01 |
| HUMAN-TRIAL | evidence | Blinded by the drug? A vigilyze signal linking semaglutide to NAION. | Ozempic | Glycemic control · human-observational | 2025-09-30 |
| HUMAN-TRIAL | evidence | Efficacy of once-weekly semaglutide in patients with heart failure with preserved ejection fraction, obesity and type 2 diabetes. | semaglutida | human-observational | 2025-09-01 |
| HUMAN-TRIAL | evidence | Harnessing Facebook to Investigate Real-World Mentions of Adverse Events of Glucagon-Like Peptide-1 Receptor Agonist (GLP-1 RA) Medications: Observational Study of Facebook Posts From 2022 to 2024. | Ozempic | Glycemic control · human-observational | 2025-07-24 |
| HUMAN-TRIAL | evidence | TikTok's take on adverse effects for glucagon-like peptide-1 and gastric inhibitory polypeptide receptor agonists. | Ozempic | human-observational | 2025-07-01 |
| HUMAN-TRIAL | evidence | Prescriptions for Obesity Medications Among Adolescents Aged 12-17 Years with Obesity - United States, 2018-2023. | Wegovy | Weight & fat loss · human-observational | 2025-06-05 |
| HUMAN-TRIAL | evidence | Obesity and Metabolic Disease Impair the Anabolic Response to Protein Supplementation and Resistance Exercise: A Retrospective Analysis of a Randomized Clinical Trial with Implications for Aging, Sarcopenic Obesity, and Weight Management. | Ozempic | Muscle growth & preservation · human-rct | 2024-12-23 |
| HUMAN-TRIAL | evidence | [The GLP-1 analogue battle: effects of semaglutide 0,5 mg/weekly versus liraglutide 3 mg/daily on anthropometric parameters after 3 months in a real world-scenario]. | semaglutida | Weight & fat loss · human-observational · n = 179 | 2024-12-19 |
| HUMAN-TRIAL | evidence | Efficacy and safety of semaglutide: real-world tertiary care experience from Saudi Arabia. | Ozempic | Glycemic control · human-observational | 2024-11-01 |
| HUMAN-TRIAL | evidence | Real-World Use of Semaglutide for Weight Management: Patient Characteristics and Dose Titration-A Danish Cohort Study. | Wegovy | Glycemic control · human-observational · n = 110748 | 2024-10-01 |
| HUMAN-TRIAL | evidence | [Oral semaglutide, first oral GLP-1 receptor agonist (Rybelsus(R))]. | Rybelsus | Glycemic control · human-rct | 2021-12-01 |
| HUMAN-TRIAL | evidence | Long Term Comparative Effectiveness of Once Weekly Semaglutide Versus Standard of Care in a Real World Adult US Population With Type 2 Diabetes - a Randomized Pragmatic Trial | Semaglutide | Glycemic control · human-rct · n = 1278 | — |
| HUMAN-TRIAL | evidence | A Research Study to Look at How Insulin 287 and Semaglutide Work in the Body of People With Type 2 Diabetes When Taken Alone or Together | Ozempic | Glycemic control · human-rct · n = 30 | — |
| HUMAN-TRIAL | evidence | Repurposing Semaglutide for the Treatment of Cocaine Use Disorder | Semaglutide | human-rct · n = 75 | — |
| HUMAN-TRIAL | evidence | GLP-1 Medication & Behavioral Health Programs on Weight & Metabolic Outcomes: FLOURISH and THRIVE Prospective Cohort Study | Semaglutide | Weight & fat loss · human-observational · n = 2310 | — |
| HUMAN-TRIAL | evidence | A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Canada, as Part of Local Clinical Practice | Semaglutide | Glycemic control · human-observational · n = 194 | — |
| HUMAN-TRIAL | evidence | A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Spain, as Part of Local Clinical Practice | Semaglutide | Glycemic control · human-observational · n = 465 | — |
| HUMAN-TRIAL | evidence | Retrospective Analysis for Patients With Metabolic Syndrome | Semaglutide | human-observational · n = 400 | — |
| HUMAN-TRIAL | evidence | Post-Marketing Surveillance (Special Use-results Surveillance) on Long-term Use With Ozempic® | Semaglutide | Glycemic control · human-observational · n = 3217 | — |
| HUMAN-TRIAL | evidence | Holding vs. Continuing Incretin-based Therapies Before Upper Endoscopy | Semaglutide | human-rct · n = 69 | — |
| HUMAN-TRIAL | evidence | Effects of Dapagliflozin, Semaglutide, and Their Combination in Heart Failure Patients With Prosthetic Heart Valves | Semaglutide | Lipid & cardiovascular markers · human-rct · n = 160 | — |
| HUMAN-TRIAL | evidence | Emulating the PIONEER6 Diabetes Trial Using Healthcare Claims | Semaglutide | Glycemic control · human-observational · n = 26126 | — |
| HUMAN-TRIAL | evidence | A Trial Investigating the Influence of Oral Semaglutide on the Pharmacokinetics of Lisinopril and Warfarin in Healthy Subjects | Semaglutide | Glycemic control · human-observational · n = 52 | — |
| HUMAN-TRIAL | evidence | Efficacy and Safety of Semaglutide Versus Canagliflozin as add-on to Metformin in Subjects With Type 2 Diabetes | Semaglutide | Glycemic control · human-rct · n = 788 | — |
| HUMAN-TRIAL | evidence | Impact of Semaglutide on Tobacco Use and Related Health Behaviors | Ozempic | human-rct · n = 40 | — |
| HUMAN-TRIAL | evidence | GLP-1 Receptor Agonist in Primary Intracerebral Hemorrhage: A Phase 2 Randomized Trial | Semaglutide | human-rct · n = 200 | — |
| HUMAN-TRIAL | evidence | Anti-obesity Pharmacotherapy and Inflammation | Wegovy | Weight & fat loss · human-observational · n = 30 | — |
| HUMAN-TRIAL | evidence | Alleviating Carbohydrate Counting for Patients with Type-1 Diabetes Using a Closed Loop System with Weekly Subcutaneous Semaglutide | Semaglutide | Glycemic control · human-rct · n = 26 | — |
| HUMAN-TRIAL | evidence | Efficacy and Safety of Semaglutide Once-weekly Versus Sitagliptin Once-daily as add-on to Metformin and/or TZD in Subjects With Type 2 Diabetes | Semaglutide | Glycemic control · human-rct · n = 1231 | — |
| HUMAN-TRIAL | evidence | Semaglutide in CFRD | Semaglutide | Glycemic control · n = 8 | — |