| HUMAN-TRIAL | evidence | Association of serum thymosin beta4 with malnutrition-inflammation-atherosclerosis syndrome in peritoneal dialysis patients: a cross-sectional study. | Thymosin beta 4 | Inflammation · human-observational · n = 76 | 2023-12-01 |
| HUMAN-TRIAL | evidence | 0.1% RGN-259 (Thymosin ss4) Ophthalmic Solution Promotes Healing and Improves Comfort in Neurotrophic Keratopathy Patients in a Randomized, Placebo-Controlled, Double-Masked Phase III Clinical Trial. | RGN-259 | Eye & vision health · human-rct | 2022-12-29 |
| HUMAN-TRIAL | evidence | Role of Thymosin Beta 4 in the diagnosis of Nonalcoholic Fatty Liver and its relation to Metabolic Syndrome in Egyptian patients. | Tbeta4 | Glycemic control · human-observational · n = 80 | 2022-04-01 |
| HUMAN-TRIAL | evidence | Association between Thymosin beta-4, acute kidney injury, and mortality in patients with sepsis: An observational cohort study. | Tbeta4 | Kidney function · human-observational | 2021-12-01 |
| HUMAN-TRIAL | evidence | A first-in-human, randomized, double-blind, single- and multiple-dose, phase I study of recombinant human thymosin beta4 in healthy Chinese volunteers. | Thymosin beta 4 | human-rct | 2021-09-01 |
| HUMAN-TRIAL | evidence | Identification of altered protein expression in major depressive disorder and bipolar disorder patients using liquid chromatography-tandem mass spectrometry. | Thymosin beta 4 | Mood & anxiety · human-observational · n = 138 | 2021-05-01 |
| HUMAN-TRIAL | evidence | F-Actin is associated with a worsening qSOFA score and intensive care unit admission in emergency department patients at risk for sepsis. | Thymosin beta 4 | Inflammation · human-observational · n = 203 | 2020-07-01 |
| HUMAN-TRIAL | evidence | Thymosin beta-4 overexpression correlates with high-risk groups in gastric gastrointestinal stromal tumors: A retrospective analysis by immunohistochemistry. | Tbeta4 | Gut barrier & GI healing · human-observational | 2017-09-01 |
| HUMAN-TRIAL | evidence | Thymosin Beta-4 Is Elevated in Women With Heart Failure With Preserved Ejection Fraction. | TB4 | Lipid & cardiovascular markers · human-observational · n = 657 | 2017-06-13 |
| HUMAN-TRIAL | evidence | The expression of thymosin beta4 in chronic hepatitis B combined nonalcoholic fatty liver disease. | Tbeta4 | Inflammation · human-observational · n = 88 | 2016-12-01 |
| HUMAN-TRIAL | evidence | Safety and efficacy of autologous thymosin beta4 pre-treated endothelial progenitor cell transplantation in patients with acute ST segment elevation myocardial infarction: A pilot study. | Tbeta4 | human-rct | 2016-08-01 |
| HUMAN-TRIAL | evidence | Increases in plasma Tbeta4 after intracardiac cell therapy in chronic ischemic heart failure is associated with symptomatic improvement. | Tbeta4 | Lipid & cardiovascular markers · human-rct | 2015-05-01 |
| HUMAN-TRIAL | evidence | Thymosin beta4 significantly improves signs and symptoms of severe dry eye in a phase 2 randomized trial. | RGN-259 | Eye & vision health · human-rct | 2015-05-01 |
| HUMAN-TRIAL | evidence | Significant decrease in plasma N-acetyl-seryl-aspartyl-lysyl-proline level in patients with end stage renal disease after kidney transplantation. | Thymosin β4 | Kidney function · human-observational | 2014-01-01 |
| HUMAN-TRIAL | evidence | Increased thymosin beta4 levels in the serum and SF of knee osteoarthritis patients correlate with disease severity. | Thymosin beta 4 | Bone & joint health · human-observational · n = 368 | 2013-08-10 |
| HUMAN-TRIAL | evidence | Thymosin beta4 is a novel potential prognostic marker in gastrointestinal stromal tumors. | Tbeta4 | Gut barrier & GI healing · human-observational · n = 60 | 2012-09-01 |
| HUMAN-TRIAL | evidence | Association between serum thymosin beta4 levels of rheumatoid arthritis patients and disease activity and response to therapy. | Tbeta4 | Inflammation · human-observational · n = 40 | 2012-08-01 |
| HUMAN-TRIAL | evidence | Contribution of cerebrospinal fluid thymosin beta4 levels to the clinical differentiation of Creutzfeldt-Jakob disease. | Thymosin beta 4 | Cognition & memory · human-observational · n = 88 | 2012-07-01 |
| HUMAN-TRIAL | evidence | Thymosin beta4 levels after successful primary percutaneous coronary intervention for acute myocardial infarction. | Tbeta4 | Lipid & cardiovascular markers · human-observational · n = 48 | 2011-12-01 |
| HUMAN-TRIAL | evidence | Intraocular expression of thymosin beta4 in proliferative diabetic retinopathy. | Thymosin beta 4 | Glycemic control · human-observational · n = 86 | 2011-08-01 |
| HUMAN-TRIAL | evidence | A randomized, placebo-controlled, single and multiple dose study of intravenous thymosin beta4 in healthy volunteers. | Tbeta4 | human-rct | 2010-04-01 |
| HUMAN-TRIAL | evidence | The effect of thymosin treatment of venous ulcers. | Tbeta4 | human-rct | 2010-04-01 |
| HUMAN-TRIAL | evidence | Thymosin beta-4 and venous ulcers: clinical remarks on a European prospective, randomized study on safety, tolerability, and enhancement on healing. | Tbeta4 | Wound healing · human-rct | 2007-09-01 |
| HUMAN-TRIAL | evidence | Distribution of thymic hormones in thymic tumors and myasthenic thymus. | Thymosin beta 4 | Longevity & cellular aging · human-observational · n = 44 | 1996-01-01 |
| HUMAN-TRIAL | evidence | Modulation of thymosin alpha 1 and thymosin beta 4 levels and peripheral blood mononuclear cell subsets during experimental rhinovirus colds. | Thymosin beta 4 | Immune function · human-observational · n = 38 | 1989-01-01 |
| HUMAN-TRIAL | evidence | Assessment of the Safety and Efficacy of RGN-259 Ophthalmic Solutions for Dry Eye Syndrome : ARISE-2 | RGN-259 | Eye & vision health · human-rct · n = 601 | — |
| HUMAN-TRIAL | evidence | Safety and Efficacy of Thymosin Beta 4 Ophthalmic Solution in Patients With Dry Eye | RGN-259 | Eye & vision health · human-rct · n = 72 | — |
| HUMAN-TRIAL | evidence | A Phase 1b Study of Thymosin Beta 4 in Healthy Volunteers | Thymosin beta 4 | human-rct · n = 30 | — |
| HUMAN-TRIAL | evidence | A Phase 1a Study of Thymosin Beta 4 in Healthy Volunteers | Thymosin beta 4 | human-rct · n = 54 | — |
| HUMAN-TRIAL | evidence | A Phase 2 Study on Effect of Thymosin Beta 4 on Wound Healing in Patients With Epidermolysis Bullosa | Thymosin beta 4 | human-rct · n = 30 | — |
| HUMAN-TRIAL | evidence | Comparative Study of Thymosin Beta 4 Eye Drops vs. Vehicle in the Treatment of Severe Dry Eye | Tβ4 | Eye & vision health · human-rct · n = 9 | — |
| HUMAN-TRIAL | evidence | A Phase 2 Study of the Safety and Efficacy of Thymosin Beta 4 for Treating Corneal Wounds | RGN-259 | Glycemic control · human-rct · n = 12 | — |
| HUMAN-TRIAL | evidence | Assessment of the Safety and Efficacy Study of RGN-259 Ophthalmic Solutions for Neurotrophic Keratopathy : SEER-1 | RGN-259 | human-rct · n = 18 | — |
| HUMAN-TRIAL | evidence | Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2 | RGN-259 | human-rct · n = 70 | — |
| HUMAN-TRIAL | evidence | Study of Thymosin Beta 4 in Patients With Venous Stasis Ulcers | Tβ4 | human-rct · n = 72 | — |
| HUMAN-TRIAL | evidence | TB-500 (Thymosin Beta 4 17-23 Fragment) for Cardiovascular Biomarkers in Stable ASCVD | TB500 | Lipid & cardiovascular markers · human-rct · n = 80 | — |
| HUMAN-TRIAL | evidence | A Phase 1 Safety Study of the Intravenous Administration of Thymosin Beta in Healthy Volunteers | Thymosin beta 4 | human-rct | — |
| HUMAN-TRIAL | evidence | Recombinant Human Thymosin Beta 4 for Injection(NL005) for Acute Myocardial Infarction | Thymosin beta 4 | human-rct · n = 189 | — |
| HUMAN-TRIAL | evidence | A Study of the Safety and Efficacy of Injectable Thymosin Beta 4 for Treating Acute Myocardial Infarction | Tβ4 | human-rct | — |
| HUMAN-TRIAL | evidence | Assessment of the Safety and Efficacy of RGN-259 Ophthalmic Solutions for Dry Eye Syndrome: ARISE-1 | RGN-259 | Eye & vision health · human-rct · n = 317 | — |
| HUMAN-TRIAL | evidence | Slow-release Tb4 Collagen and Chitosan Porous Sponge Scaffolds Skin Substitute Treatment is Difficult to Heal Wounds | TB4 | n = 20 | — |
| HUMAN-TRIAL | evidence | Assessment of the Safety and Efficacy of RGN-259 Ophthalmic Solutions for Dry Eye Syndrome: ARISE-3 | RGN-259 | Eye & vision health · human-rct · n = 700 | — |
| HUMAN-TRIAL | evidence | Study of Thymosin Beta 4 in Patients With Pressure Ulcers | Thymosin beta 4 | human-rct · n = 72 | — |
| REGULATORY | regulatory | D-0087-2026 — Thymosin Beta-4 (TB4) for Injection, 15mg, all presentations, GenoGenix, LLC, 2840 NW 2nd Ave Ste 204 Boca Raton, FL 33431-6692. | FDA | — | 2025-07-30 |
| REGULATORY | regulatory | D-0086-2026 — BPC-157/Thymosin Beta-4 for Injection, a) 10/10mg, b) 15/15mg, c) 15mg/15mg, all presentations, GenoGenix, LLC, 2840 NW 2nd Ave Ste 204 Boca Raton, FL 33431-6692. Also labeled as manufactured for CELIA Health, Extension Health and Medical Health Institute (MHI). | FDA | — | 2025-07-30 |
| REGULATORY | regulatory | D-0140-2021 — THYMOSIN BETA - 4, 2000 MCG/ML, 5 ML vial, The Guyer Institute of Molecular Medicine, Indianapolis, IN | FDA | — | 2020-11-30 |
| REGULATORY | regulatory | D-0447-2019 — Thymosin Beta-4, 15 mg Injection, Rx Only, Promise Pharmacy Compounding Specialists 31818 US Hwy 19N, Palm Harbor, FL 34684 | FDA | — | 2018-12-17 |
| ANIMAL | evidence | Reparative Outcomes in Corneal Infection: Linking Adjunctive Tbeta4 Treatment to Nerve Regeneration and Visual Function. | Tbeta4 | Neuroprotection · animal | 2026-06-01 |
| ANIMAL | evidence | Prelimbic cortex to ventral tegmental area projection regulates early social isolation stress-potentiated heroin seeking in mice. | Thymosin β4 | Mood & anxiety · animal | 2025-10-29 |
| ANIMAL | evidence | Comparative effects of dietary sodium butyrate and tributyrin on broiler chickens' performance, gene expression, intestinal histomorphometry, blood indices, and litter. | TB 500 | animal | 2025-07-18 |