| INDEPENDENT-REVIEW | review | Anyone in New Zealand have Retatrutide source?
Looking for a reputable source in NZ for retatrutide | COMMUNITY | — | 2025-10-28 |
| INDEPENDENT-REVIEW | review | If you hit a plateau you should increase the dose as 1mg is a low dose . I started at 2.5 and have been up to 8 mg a week. Now lost 4 stone and sitting at 12.2 stone and taking 4 mg to slow the weight loss . You need to concentrate on high protein low carb diet and move more then you will break the plateau. My current stack is retatrutide 4mg a week tesamorelin 2mg every night before bed GHK-Cu | COMMUNITY | — | 2025-10-28 |
| INDEPENDENT-REVIEW | review | I will not give advice on dosage as I do not feel that I am an expert. Hopefully others will chime in. I have been doing 1 mg, every other day for 2 months. I am down from low 190’s to low 170’s. Hit 169.9 yesterday morning and at 170.8 this morning. My starting weight was 281. I started on Mounjaro. Each time I plateau, I introduce a different thing to shake it up. Quit drinking for 8 | COMMUNITY | — | 2025-10-28 |
| INDEPENDENT-REVIEW | review | I will have to disagree with you, at the moment there is only one GLP that is oral and that is Rybelsus which contains semaglutide. Tirzepatide and Retatrutide do not have any at the moment | COMMUNITY | — | 2025-10-28 |
| INDEPENDENT-REVIEW | review | I have the same sentiment as OP, so my follow-up question to your answer is, why not a smaller dose of Semaglutide in conjunction with Retatrutide if appetite suppression is the goal since Sema has strong properties? Any additional advantage behind Cagri? | COMMUNITY | — | 2025-10-28 |
| INDEPENDENT-REVIEW | review | I have heard the alcohol can be an allergen, the actual Retatrutide can cause allergic reactions, as well as any fillers/leftover reagents from the production can be as well. As for why that specific brand, if you can find the legit hospira brand stuff, that is the gold standard of bac water. It is what hospitals use, and it is actually manufactured to very very strict health standards. When you | COMMUNITY | — | 2025-10-28 |
| INDEPENDENT-REVIEW | review | Retatrutide and cardio endurance
[removed] | COMMUNITY | — | 2025-10-28 |
| INDEPENDENT-REVIEW | review | I dont understand any of his post lol. I thought he was only taking retatrutide but I guess not ? | COMMUNITY | — | 2025-10-28 |
| INDEPENDENT-REVIEW | review | I was struggling at getting down from 1 1/2 to 2 a day. I was drinking 4 a day for over a year . When I was titrating down I was sooo low like low mood low in sleep low in energy low in motivation. I did a deep dive on peptides and got on retatrutide which totally interrupts the dopamine loop and almost makes it not work… like it helped me get down from 2/ day to zero. The nad, ss31, and | COMMUNITY | — | 2025-10-28 |
| INDEPENDENT-REVIEW | review | def didnt execute the explanation right off the other 2 comments 😭 but it basically went that unprescribed retatrutide is currently unethical but there is a future potential for the drug, especially after it gets FDA approved | COMMUNITY | — | 2025-10-28 |
| INDEPENDENT-REVIEW | review | hi friend! retatrutide can be ethical for users under principles such as autonomy and CI2. i completely agree that there is an ethical issue of users autonomy being compromised when they make choices without medical guidance or education. i have already submitted the first part of my assignment about retatrutide being ethical; a professional in the field enjoyed my essay 😊 | COMMUNITY | — | 2025-10-27 |
| INDEPENDENT-REVIEW | review | Retatrutide’s effect on dopamine isn’t fully mapped, but GLP-1 receptor agonists can impact dopamine signaling and reduce reward related responses for some users, which may blunt mood boosts from activities or substances. You did right by stopping and letting things normalize. Alternatives like tesamorelin or CJC-1295/ipamorelin stacks may be less likely to affect dopamine. This reply is for | COMMUNITY | — | 2025-10-27 |
| INDEPENDENT-REVIEW | review | 12mg Retatrutide
1.2ml Bac water
Pull Syringe to 0.4ml
Each injection = 0.5g of Reta | COMMUNITY | — | 2025-10-27 |
| INDEPENDENT-REVIEW | review | Anyone else feel retatrutide negatively effects their dopamine response
I was on reta for 2 months back in the summer (1.5 mg a week) and though I got the results I was looking for (losing the last 10 lbs that I could NEVER lose before), there was one big negative that effected my overall experience with it and that was the feeling of having low dopamine or the lack of a dopamine hit.
This | COMMUNITY | — | 2025-10-27 |
| INDEPENDENT-REVIEW | review | You added a lot of unnecessary information. For others to help let them know your dosage strength not the units or how you reconstituted it. 5 mg vial with 3 mL BAC water and assuming a 1 mL needle means 30 units is 0.5 mg.
First you're going to feel super hungry because Semaglutide is a better appetite suppressant than Retatrutide. Reta has other things in it that ultimately makes it a better | COMMUNITY | — | 2025-10-27 |
| INDEPENDENT-REVIEW | review | Retatrutide
[removed] | COMMUNITY | — | 2025-10-27 |
| INDEPENDENT-REVIEW | review | I think that anhedonia is a pretty common side effect from Retatrutide. This may reflect in a dulled social life, but also extends well beyond into other interests. Personally I feel just more *dulled*. I'm usually easily excitable like a puppy dog, but since going on Reta a few months ago, the pounds have flown off but as has my excitability. | COMMUNITY | — | 2025-10-27 |
| INDEPENDENT-REVIEW | review | I was on tirzepatide for almost 3 years before switching to retatrutide. While they both have caused significant fatigue for me, the reta seems to be slightly better? Tirz was like flu-level fatigue for a few days/week and never got better over the years. I am willing to accept the side effect, as being fat was also fatiguing. | COMMUNITY | — | 2025-10-27 |
| INDEPENDENT-REVIEW | review | It IS real. I experienced it too! I also read a lot about “just eat more blah blah” but it doesnt help.
ChatGPT writes:
“Retatrutide activates GLP-1 receptors in the brain, particularly in the hypothalamus and brainstem.
This helps suppress appetite but also influences arousal networks that keep you alert.
As a result, many people experience central fatigue — a kind of mental tiredness or | COMMUNITY | — | 2025-10-27 |
| INDEPENDENT-REVIEW | review | I believe everyone is different…. I’ve lost absolutely nothing with Retatrutide (been on for over 2 months) and am considering going back to Tirzepatide … 🤷🏻♀️ | COMMUNITY | — | 2025-10-27 |
| INDEPENDENT-REVIEW | review | Retatrutide progress
First picture 9/11/25 second 10/27/25
2 mg every 5 days. Hunger in gone. Now for my second month I’ll do 2.5 mg into 3 pins a week. For a more steady level. Please share your opinions and suggestions. | COMMUNITY | — | 2025-10-27 |
| INDEPENDENT-REVIEW | review | Retatrutide Progress.
[removed] | COMMUNITY | — | 2025-10-27 |
| INDEPENDENT-REVIEW | review | It sounds like you’ve made incredible progress with your relationship to food and sugar, but now your body’s telling you it’s time to find a middle ground. You’ve clearly gained control over the binge cycle, which is huge, and you deserve to feel good in your body *and* healthy.
If you’re on 2 mg of Reta (Retatrutide) weekly and stable at 111 lbs, that’s a pretty strong signal that your | COMMUNITY | — | 2025-10-27 |
| INDEPENDENT-REVIEW | review | You really think I'd ask for help in a public forum if I were actually trying to smuggle drugs? I don't want to be jailed in Dubai. Damn guys Dubai is not easy I wouldn't risk it for drugs plus I don't even do drugs. This is RETATRUTIDE AND GHK CU 😭 | COMMUNITY | — | 2025-10-27 |
| INDEPENDENT-REVIEW | review | Retatrutide Users: Thermodynamics Still Rules the Game (Don’t Skip the Fundamentals)
A lot of people jumping on retatrutide right now think it’s basically a “delete fat” button. And yeah, the mechanisms are insane — triple agonism hitting appetite regulation, energy expenditure, and metabolic pathways. You can burn more and want to eat less.
Weight loss still comes down to burning more calories | COMMUNITY | — | 2025-10-27 |
| INDEPENDENT-REVIEW | review | Orforglipron is what you’re looking for. It’s not as strong as retatrutide, it’s comparable to semaglutide (Ozempic).
It’s a bit further along in development than retatrutide in that it has completed phase 3 trials and is now moving towards FDA approval. It’s still not available through your doctor and won’t be until it gets that approval (same with reta) but it recently became available on | COMMUNITY | — | 2025-10-27 |
| INDEPENDENT-REVIEW | review | What a load of shit... Tirzepatide is significantly less effective than Retatrutide based purely on receptor agonism... it has a stronger effect of both receptors that Tirzepatide works on plus is also a Glucagon receptor agonist...
sema = longer acting but same glp1 benefit as human glp1
reta = 2.5x less glp1 benefit as sema; and 2X that of tirz
reta = 8.9 X gip benefit | COMMUNITY | — | 2025-10-27 |
| INDEPENDENT-REVIEW | review | Day 5 on Retatrutide – Down 2kg Already!
So I’m on my 5th day of my journey with Retatrutide (2mg weekly) and I’ve already lost 2kg.
Side effects so far:
• Mild fatigue during the first two days
• Appetite noticeably reduced but not gone
• Food noise canceled almost immediately
• Still enjoy eating, but portions are way smaller now (like I used to eat 4–5 slices of pizza, now 2 is | COMMUNITY | — | 2025-10-27 |
| INDEPENDENT-REVIEW | review | Anyone else come across SIBO while researching or using Retatrutide?
I recently started Retatrutide and stopped in week two after learning more about SIBO (Small Intestinal Bacterial Overgrowth) — and I wanted to open a discussion here.
SIBO happens when bacteria that normally live in the large intestine start growing in the small intestine instead. This can lead to symptoms like bloating, | COMMUNITY | — | 2025-10-27 |
| INDEPENDENT-REVIEW | review | Anyone else come across SIBO while researching or using Retatrutide?
I recently started Retatrutide and stopped in week two after learning more about SIBO (Small Intestinal Bacterial Overgrowth) — and I wanted to open a discussion here.
SIBO happens when bacteria that normally live in the large intestine start growing in the small intestine instead. This can lead to symptoms like bloating, | COMMUNITY | — | 2025-10-27 |
| INDEPENDENT-REVIEW | review | I think it's best that the complainers just stop taking retatrutide. And wait for the imaginary medication comes along with zero side effects. | COMMUNITY | — | 2025-10-27 |
| INDEPENDENT-REVIEW | review | New to Retatrutide
I am just starting this and need some help regarding dosages. I want to micro dose and I am just not sure how much bacteriostatic water one adds to a vial say of 10ml Peptide?
So say I want 1mg of peptide every week. Can someone give me some guidlelines.
I don't really want to lose too much weight. I am wanting to try it for muscle recover and autoimmune issues (Hashimotos). | COMMUNITY | — | 2025-10-27 |
| INDEPENDENT-REVIEW | review | If you're going to use AI answers, you need to ask the question a minimum of two ways and compare the responses. You will be shocked at the direct contradictions you'll get.
Hey Google AI, does retatrutide cause mitochondrial *uncoupling*?
> *There is no current evidence that retatrutide causes mitochondrial uncoupling.* In fact, the available preclinical data suggest that the glucagon | COMMUNITY | — | 2025-10-27 |
| INDEPENDENT-REVIEW | review | Hi, new. Nice to meet you.
Sounds like you have a lot of retatrutide research to do before you start chatting more on this subreddit. Read the entire phase 2 trial of retatrutide before you continue. | COMMUNITY | — | 2025-10-27 |
| INDEPENDENT-REVIEW | review | I’ve been dealing with fatigue but I’ve been coming out of a bodybuilding contest prep in and added in retatrutide for its benefits on hb1ac, ldl and inflammation.
Got a full blood panel done Friday and am awaiting the results which should hopefully come back today to ascertain if it’s due to retatrutide, over training or from just being too far away from my bodyfat set point.
It could also | COMMUNITY | — | 2025-10-26 |
| INDEPENDENT-REVIEW | review | Nice! Retatrutide removed the heart tattoo on your right bicep. Keep up the good work! | COMMUNITY | — | 2025-10-26 |
| INDEPENDENT-REVIEW | review | Oh shit, I thought with the glucagon it did.
Google AI
Yes, retatrutide does contribute to mitochondrial uncoupling, primarily through its action as a glucagon receptor agonist
. This uncoupling is a key part of how the drug increases energy expenditure and promotes fat burning, leading to significant weight | COMMUNITY | — | 2025-10-26 |
| INDEPENDENT-REVIEW | review | Hello, what is price for Retatrutide? | COMMUNITY | — | 2025-10-26 |
| INDEPENDENT-REVIEW | review | You should be using bacteriostatic water (sterile water for injection + 0.9% benzyl alcohol).
You should *not* be using sterile water (without benzyl alcohol) unless you intend to use your vial as a single-dose vial and dispose of any remaining contents after immediate use.
You should *not* be using any product containing sodium or NaCl such as bacteriostatic saline as it is incompatible with | COMMUNITY | — | 2025-10-26 |
| INDEPENDENT-REVIEW | review | « Im feeling tired and im not Even in a calorie deficit »
Then why the fuck are you on retatrutide losing time posting this?
Please include yourself. Losing Time answering lmfao | COMMUNITY | — | 2025-10-26 |
| INDEPENDENT-REVIEW | review | Retatrutide has been shown to cause a **dose-dependent increase in heart rate**, with reported rises of up to 6.7 beats per minute in clinical trials
[Retatrutide showing promise in obesity (and type 2 diabetes)](https://www.tandfonline.com/doi/full/10.1080/13543784.2023.2283020) "heart rate was increased by up to 6.7 beats/min by retatrutide"
[Retatrutide: a triple incretin receptor agonist | COMMUNITY | — | 2025-10-26 |
| INDEPENDENT-REVIEW | review | Either its a ragebait
If its not, please uninstall Reddit, and Forget how you went to get Retatrutide. | COMMUNITY | — | 2025-10-26 |
| INDEPENDENT-REVIEW | review | The logic in your post doesn’t line up with how body composition actually works. Most people underestimate how much fat they’re carrying and how much needs to be lost before they’re actually lean. Dropping 5 kg might sound significant, but unless you’re already sitting around ~15 % body fat, that’s barely a visual difference. Retatrutide or any glucagon agonist doesn’t magically make you “lean | COMMUNITY | — | 2025-10-26 |
| INDEPENDENT-REVIEW | review | Retatrutide dosing | COMMUNITY | — | 2025-10-26 |
| INDEPENDENT-REVIEW | review | Reta is supposed to be better for maintaining heart health and muscle preservation. However, the appetite suppression is far better with tirzepatide. I'm titrating down tirz and up retatrutide now. Weight has been stable but the food noise is with me again. Not bad and I'm getting full very fast. | COMMUNITY | — | 2025-10-26 |
| INDEPENDENT-REVIEW | review | Why are you gatekeeping a peptide that has value for all? If you’re so keen on keeping it to general population users, maybe try Retatrutide for absolute newbies on facebook. thats a great echo chamber for people who want to be spoon fed by the moderators who are self proclaimed experts. | COMMUNITY | — | 2025-10-26 |
| INDEPENDENT-REVIEW | review | You are wrong on both accounts. It's not an illegal drug. It's a "grey" drug meaning that it can't be sold for human consumption. No one to my knowledge has been arrested for these drugs unless they are giving medical info or selling them for non research purposes.
Youtube has actual videos of people injecting Retatrutide They don't have videos of people injecting steroids as it is illegal | COMMUNITY | — | 2025-10-26 |
| INDEPENDENT-REVIEW | review | You must be new to Reddit?
I'm biased because I am in the group of people you dislike posting here, a bodybuilder who used Retatrutide to great success during his competition. I won't post my success story in here any more because it's not the right audience but I don't agree with the weight-loss crowd gatekeeping what is still a grey-market drug.
The fitness community and bodybuilders have | COMMUNITY | — | 2025-10-26 |
| INDEPENDENT-REVIEW | review | Switching from Tirzepatide to Retatrutide — the non-linear truth
If you’re coming off Tirz and jumping to Reta, brace for a totally different ride.
1️⃣ Non-linear dose response
With Tirz, more dose = more effect. Even low doses feel like something.
With Reta, it’s different. Think tools:
Tirz = tap hammer → lots of hits, nail finally goes in
Reta = sledgehammer → needs full power swings or | COMMUNITY | — | 2025-10-26 |
| INDEPENDENT-REVIEW | review | No gallbladder & Retatrutide
Anyone successfully using Retatrutide that doesn’t have a gallbladder? | COMMUNITY | — | 2025-10-26 |